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  4. TNIP2 Antibody

TNIP2 Antibody

  • 中文名稱：
    TNIP2兔多克隆抗體
  • 貨號：
    CSB-PA713993
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TNIP2
  • 別名：
    A20 binding inhibitor of NF kappaB activation 2 antibody; A20-binding inhibitor of NF-kappa-B activation 2 antibody; ABIN 2 antibody; ABIN-2 antibody; Fetal liver LKB1-interacting protein antibody; FLIP1 antibody; KLIP antibody; LKB1 interacting protein antibody; TNFAIP3 interacting protein 2 antibody; TNFAIP3-interacting protein 2 antibody; TNIP2 antibody; TNIP2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 61-110
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
  • 基因功能參考文獻：
    1. RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
    2. Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
    3. Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
    4. miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
    5. ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
    6. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
    7. transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
    8. FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
    9. Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
    10. ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
    11. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
    12. optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
    13. ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
    14. Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
    15. Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
    16. role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
    17. This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Ubiquitously expressed in all tissues examined.
  • 數據庫鏈接：

    HGNC: 19118

    OMIM: 610669

    KEGG: hsa:79155

    STRING: 9606.ENSP00000321203

    UniGene: Hs.368551



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