在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TNFRSF10D Antibody

  • 中文名稱:
    TNFRSF10D兔多克隆抗體
  • 貨號:
    CSB-PA057438
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA057438(TNFRSF10D Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA057438(TNFRSF10D Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD 264 antibody; CD264 antibody; DcR 2 antibody; DcR2 antibody; Decoy receptor 2 antibody; Decoy with truncated death domain antibody; OTTHUMP00000123528 antibody; TNF receptor related receptor for TRAIL antibody; TNF related apoptosis inducing ligand receptor 4 antibody; TNF-related apoptosis-inducing ligand receptor 4 antibody; TNFRSF 10D antibody; TNFRSF10D antibody; TR10D_HUMAN antibody; TRAIL R4 antibody; TRAIL receptor 4 antibody; TRAIL receptor with a truncated death domain antibody; TRAIL-R4 antibody; TRAILR4 antibody; TRUNDD antibody; Tumor necrosis factor receptor superfamily member 10D antibody; Tumor necrosis factor receptor superfamily; member 10d; decoy with truncated death domain antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Fusion protein of Human TNFRSF10D
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
  • 基因功能參考文獻:
    1. The high-dose hook effect was apparent during ELISA testing of uDcR2 in chronic kidney disease (CKD) patients, yet dilution of the urine samples neutralized this effect. However, the use of a four-fold dilution of urine for uDcR2/cre testing may eliminate the high-dose hook effect and make it possible to effectively monitor the severity of TII in CKD patients. PMID: 29879421
    2. results suggest that CD264 is a surface marker of cellular age for bone marrow-derived mesenchymal stem cells. PMID: 28962588
    3. Urinary DcR2 could potentially serve as a novel biomarker for tubulointerstitial injury and may reflect senescence of renal proximal tubular cells in diabetic nephropathy. PMID: 28356293
    4. Results identified epigenetic inactivation of TNFRSF10C and TNFRSF10D in majority of cervical cancer cases. PMID: 26542757
    5. membrane expression more common in endometrioid endometrial cancer than in normal endometrium PMID: 24649804
    6. This study identified TNFRSF10D DNA methylation status as an independent prognostic biomarker for relapse-free survival and overall mortality in non-metastatic melanoma patients. PMID: 25003639
    7. The membrane expression of the TRAIL receptors DR4, DR5, DcR1 and DcR2 is greater in normal endometrium than endometrioid adenocarcinoma (EAC). The level of the receptors in EAC is not dependent on grading and staging and does not predict survival. PMID: 23584885
    8. the results presented here claim for a relevant impact of aberrant methylation of decoy receptors in melanoma and allow to understand how the silencing of DcR1 and DcR2 is related to melanomagenesis. PMID: 24211571
    9. TRAIL receptor-4 expression profiles on T cells might be important in revelation of rheumatoid arthritis pathogenesis. PMID: 20799941
    10. ANT2 shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 and DR5) and down-regulating the TRAIL decoy receptor 2 (DcR2). PMID: 20875141
    11. these results demonstrated that hypoxia-inducible factor 1alpha played a crucial role in regulating the transcription of DcR2. PMID: 20018172
    12. Enhanced expression of DcR2 promotes peripheral blood eosinophil survival in the airways of allergic asthmatics following segmental antigen challenge. PMID: 12421985
    13. Cytotoxicity and apoptosis induced by TRAIL to beta-cell lines CM were inhibited competitively by soluble TRAIL receptors, R1, R2, R3 or R4. PMID: 12488957
    14. Respiratory syncytial virus infection strongly up-regulated the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its functional receptors death receptor 4 (DR4) and DR5. PMID: 12915532
    15. Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
    16. The DcR2 was found to have a truncated and non-functional death domain. PMID: 15538968
    17. CD8+ lymphocytes and NKT lymphocytes, but not CD4+ lymphocytes, express TRAIL-R4 PMID: 15919363
    18. Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R4. PMID: 15921376
    19. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. PMID: 16319225
    20. DCR2 was found positive in 81 and 33% normal, 46 and 10% nodular hyperplasia, 74 and 36% PIN tissues, 87 and 89% low-grade carcinomas, and 100 and 93% high-grade carcinomas PMID: 16799475
    21. TRAIL-R4-beta is a new splice variant of TRAIL-receptor 4 lacking the cysteine rich domain 1 PMID: 16934748
    22. The specificity of DcR1- and DcR2-mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling. PMID: 16980609
    23. CASP8, DCR2, and HIN-1 methylation leads to progression of neuroblastoma PMID: 17545522
    24. These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors. PMID: 18460741
    25. DCR2-methylated patients showed significantly poorer 5-year event-free survival in the whole neuroblastoma group (43% PMID: 18980997
    26. High TRAIL death receptor 4 and decoy receptor 2 expression correlates with significant cell death in pancreatic ductal adenocarcinoma patients. PMID: 18981952
    27. Results indicate that disc cells, after herniation, undergo apoptotic cell death via the DR5/TRAIL pathway. PMID: 19730199

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11907

    OMIM: 603614

    KEGG: hsa:8793

    STRING: 9606.ENSP00000310263

    UniGene: Hs.213467



主站蜘蛛池模板: 狠狠色噜噜狠狠狠狠888奇禾| 国产男女猛烈无遮挡a片漫画| 欧美俄罗斯乱妇| 国产成人av免费观看| av无码人妻一区二区三区牛牛| 国产精品三级av及在线观看| 韩国国内大量揄拍精品视频| 精品久久久久久久无码| 黑森林福利视频导航| 国产suv精品一区二区6| 久久视频这里只精品99| 精品国产高清毛片a片看| av人摸人人人澡人人超碰妓女| 国产精品熟女高潮视频| 日韩乱码人妻无码中文字幕视频 | 天天摸天天碰天天添| 黑人大战中国av女叫惨了| 一区二三区国产好的精华液o9| 在线天堂资源www| 国产日产韩国精品视频| 国产精品久久久久久亚洲影视内衣 | 久热中文字幕无码视频| 农村乱人伦一区二区| 人妻少妇精品无码专区动漫| 国产精品你懂的在线播放| 成人午夜电影福利免费| 深爱婷婷国产在线精品av| 亚洲 高清 成人 动漫| 亚洲vs日韩vs欧美vs久久| 国产在线清纯极品美女援交| 丰满岳乱妇久久久| 在线观看特色大片免费网站| 色播亚洲视频在线观看| av影音先锋最大资源网| 任我爽橹在线视频精品583| 国产精品午夜无码av体验区| 精品国产乱码久久久久久浪潮| 鲁丝片一区二区三区毛片| 久久久久久成人综合网| 丰满少妇人妻无码| 成人精品一区二区三区电影|