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TNFAIP8L3 Antibody

  • 中文名稱：
    TNFAIP8L3兔多克隆抗體
  • 貨號：
    CSB-PA115238
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 1,293T 2,mouse-brain cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TNFAIP8L3
  • 別名：
    TNFAIP8L3 antibody; TIPE3 antibody; Tumor necrosis factor alpha-induced protein 8-like protein 3 antibody; TNF alpha-induced protein 8-like protein 3 antibody; TNFAIP8-like protein 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human TNFAIP8L3. at AA range: 15-45
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
  • 基因功能參考文獻：
    1. In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. (Meta-analysis) PMID: 29422769
    2. TIPE3 downregulation correlates with its CpG island hypermethylation in several solid cancers. TIPE3 acts as a tumor suppressor in nasopharyngeal carcinoma (NPC), providing a further insight into NPC progression and representing a potential prognostic biomarker for NPC PMID: 30217224
    3. High TIPE3 expression in the plasma membrane is associated with non-small-cell lung cancer. PMID: 29510688
    4. TIPE3 protein was upregulated in breast cancer tissues and positively correlated to invasion and metastasis of human breast cancer cells by activating AKT and NF-kappaB signaling pathways. PMID: 28388580
    5. Further MD simulations confirmed the dynamic stability of these lipids in the TH domain. This computational analysis thus provides insight into the binding mode of phospholipids in the TH domain of the TIPE family of proteins. PMID: 27783229
    6. TIPE3 protein is highly expressed in most human carcinoma cell lines. These results suggest that TIPE3 may play important roles in carcinogenesis and cell secretion. PMID: 25479791
    7. human cancers have markedly upregulated TIPE3 expression. Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3 expression enhances it in vivo PMID: 25242044

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  • 亞細胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    TNFAIP8 family
  • 組織特異性：
    Widely expressed (at protein level). Highly expressed in most carcinoma cell lines.
  • 數據庫鏈接：

    HGNC: 20620

    OMIM: 616438

    KEGG: hsa:388121

    UniGene: Hs.306343



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