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TMPRSS11A Antibody

  • 中文名稱:
    TMPRSS11A兔多克隆抗體
  • 貨號:
    CSB-PA138752
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA138752(TMPRSS11A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA138752(TMPRSS11A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TMPRSS11A
  • 別名:
    Airway trypsin-like protease 1 antibody; ECRG1 antibody; epidermal type II transmembrane serine protease antibody; Epidermal type-II transmembrane serine protease antibody; Esophageal cancer-susceptibility gene 1 protein antibody; TM11A_HUMAN antibody; Tmprss11a antibody; TMPRSS11A protein antibody; Transmembrane protease serine 11A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human TMPRSS11A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
  • 基因功能參考文獻:
    1. ECRG1 Arg290Gln polymorphism significantly affects the susceptibility but not the prognosis of esophageal squamous cell carcinoma patients in low-risk north Indian population. PMID: 23869757
    2. This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC. [review] PMID: 23548972
    3. Data show that the allele types of ECRG1 were Arg/Arg (54.2%), Arg/Gln (45.8%) and Gln/Gln (0.00%), and the allele types of FGFR4 amino acid 388 were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%). PMID: 23481570
    4. A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype. PMID: 21517269
    5. Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. PMID: 21288367
    6. findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control PMID: 17971341
    7. DNA polymorphisms in the coding region of ECRG1 are associated with poor outcome after surgical resection in esophageal carcinoma. PMID: 19052822
    8. no significant association between single nucleotide polymorphisms Arg/Arg, Arg/Gln and Gln/Gln and survival in oral squamous cell carcinoma PMID: 19394797
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19826048
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19394797
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19052822

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  • 亞細胞定位:
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Peptidase S1 family
  • 組織特異性:
    Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
  • 數據庫鏈接:

    HGNC: 27954

    OMIM: 611704

    KEGG: hsa:339967

    STRING: 9606.ENSP00000334611

    UniGene: Hs.450110



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