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TMLHE Antibody

  • 中文名稱:
    TMLHE兔多克隆抗體
  • 貨號:
    CSB-PA023908LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: TMLHE antibody at 2µg/ml + MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50, 47, 39, 45, 43, 42, 51 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA023908LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA023908LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TMLHE Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TMLHE
  • 別名:
    AUTSX6 antibody; BBOX2 antibody; Butyrobetaine (gamma) 2 oxoglutarate dioxygenase (gamma butyrobetaine hydroxylase) 2 antibody; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase antibody; Epsilon-trimethyllysine hydroxylase antibody; FLJ10727 antibody; TML dioxygenase antibody; TML hydroxylase antibody; TML-alpha-ketoglutarate dioxygenase antibody; TMLD antibody; TMLH antibody; TMLH_HUMAN antibody; TMLHE antibody; TMLHED antibody; Trimethyllysine dioxygenase, mitochondrial antibody; Trimethyllysine hydroxylase epsilon antibody; XAP130 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Trimethyllysine dioxygenase, mitochondrial protein (16-376AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TMLHE Antibody (CSB-PA023908LA01HU),的標記方式是Non-conjugated。對于TMLHE Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA023908LB01HU TMLHE Antibody, HRP conjugated ELISA
    FITC CSB-PA023908LC01HU TMLHE Antibody, FITC conjugated
    Biotin CSB-PA023908LD01HU TMLHE Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
  • 基因功能參考文獻:
    1. Case Report: complex recombination with deletion in the F8 and duplication in the TMLHE mediated by int22h copies during early embryogenesis in proband's mother. PMID: 28492696
    2. Study found 3 mutations in TMLHE to be associated with autism spectrum disorder, c.229C>T/p.Arg77X, c.730G>C/p.Asp244His, and c.1107G>T/p.Glu369Asp. PMID: 23092983
    3. TMLHE deficiency is common in control males and was not significantly increased in frequency in probands from simplex autism families, however, it was 2.82-fold more frequent in probands from male-male multiplex autism families. PMID: 22566635
    4. Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE. PMID: 21865298
    5. C-terminal region of trimethyllysine hydroxylase, epsilon contains the main determinants for its enzymatic activity including a key H389 residue PMID: 15754339
    6. By 5' and 3' RACE, we identified and mapped two alternative 5' TMLH first exons and seven alternative 3'-splice variants. PMID: 17408883

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  • 相關疾病:
    Autism, X-linked 6 (AUTSX6)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Gamma-BBH/TMLD family
  • 組織特異性:
    All isoforms, but isoform 8, are widely expressed in adult and fetal tissues. Isoform 8 is restricted to heart and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 18308

    OMIM: 300777

    KEGG: hsa:55217

    STRING: 9606.ENSP00000335261

    UniGene: Hs.133321



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