在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TMEFF2 Antibody

  • 中文名稱:
    TMEFF2兔多克隆抗體
  • 貨號:
    CSB-PA023667GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cancer/testis antigen family 120 member 2 antibody; CT120.2 antibody; HPP 1 antibody; HPP1 antibody; Hyperplastic polyposis protein 1 antibody; TEFF 2 antibody; TEFF2 antibody; TEFF2_HUMAN antibody; TENB 2 antibody; TENB2 antibody; TMEFF2 antibody; Tomoregulin antibody; Tomoregulin-2 antibody; TPEF antibody; TR 2 antibody; TR antibody; TR-2 antibody; Transmembrane protein containing epidermal growth factor and follistatin domains antibody; Transmembrane protein TENB2 antibody; Transmembrane protein with EGF like and two follistatin like domains 2 antibody; Transmembrane protein with EGF-like and two follistatin-like domains antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TMEFF2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
  • 基因功能參考文獻:
    1. Differential TMEFF2 processing from a single transmembrane protein may be a general mechanism to modulate transmembrane protein levels and domains, dependent on the repertoire of ADAMs or TTSPs expressed by the target cell. PMID: 28762604
    2. TMEFF2 methylation is associated with clear cell renal cell carcinoma. PMID: 28128743
    3. Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP PMID: 26402097
    4. TMEFF2 regulates the non-canonical activin/BMP4 signaling, PI3K, and Ras/ERK1/2 pathways. PMID: 25573902
    5. c-Myc contributes to the epigenetic regulation of HPP1 via the dominant recruitment of HDAC3. PMID: 24919179
    6. TMEFF2 acts as a tumor suppressor in gastric cancer through direct interaction with SHP-1 and can be a potential biomarker of carcinogenesis. PMID: 24987055
    7. TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. PMID: 23824605
    8. Androgen signaling promotes eIF2alpha phosphorylation and subsequent translation of TMEFF2 via a mechanism that requires uORFs in the 5'-UTR of TMEFF2. PMID: 23405127
    9. Methylation of TMEFF2 gene is associated with colorectal neoplasia in ulcerative colitis and Crohn's colitis. PMID: 22532293
    10. Findings suggest that methylation-associated down-regulation of TMEFF2 gene may be involved in lung tumorigenesis and TMEFF2 methylation can serve as a specific blood-based biomarker for NSCLC. PMID: 22814847
    11. Several genes expressed at exceptionally high levels were identified associated with early oocyte development, TMEFF2, the Rho-GTPase-activating protein oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6). PMID: 22238370
    12. TMEFF2 can function to regulate PDGF signaling; it is hypermethylated and downregulated in glioma and several other cancers PMID: 21559523
    13. the tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine. PMID: 21393249
    14. GDF15, HSPA2, TMEFF2, and VIM were identified as epigenetic biomarkers for Bladder cancer. PMID: 20975101
    15. Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. PMID: 12384516
    16. Aberrant methylation of the HPP1 gene is a relative common early event in ulcerative colitis-associated colorectal carcinoma. PMID: 12460892
    17. inverse correlation between TMEFF2 and c-Myc expression PMID: 12729735
    18. Hypermethylation of p16, RUNX3, and HPP1 in Barreett exophagus may represent independent risk factors for the progression of Barrett esophagus to esophageal cancer. PMID: 15824739
    19. A secreted form of TMEFF2 is expressed from TMEFF2 locus and may functionally interact with full-length TMEFF2, or its binding partners, and may also influence current immune-based treatment strategies PMID: 16439095
    20. Hypermethylation of HPP1 is associated with primary adenocarcinomas of the small bowel PMID: 16619216
    21. Methylation testing of fecal DNA using a panel of epigenetic markers (methylated SFRP2, HPP1 and MGMT) may be a simple and promising non-invasive screening method for colorectal carcinoma and precancerous lesions. PMID: 17352030
    22. TMEFF2 contributes to cell proliferation in an ADAM17-dependent autocrine fashion in cells expressing this protein PMID: 17942404
    23. data provides evidence to support the role of HPP1 as a tumor suppressor gene; activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties PMID: 18059030
    24. Methylated PAX6- or TPEF-promoters could represent biomarkers for bladder cancer. PMID: 18070176
    25. Distinct TPEF/HPP1 (transmembrane protein containing epidermal growth factor) gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis. PMID: 18799374
    26. promoter of TPEF gene is frequently hpermethylated, and associated with loss of TPEF mRNA expression in esophageal squamous cell carcinoma PMID: 19040536
    27. Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. PMID: 19288010
    28. Analysis of DNA from peripheral blood revealed that TPEF methylation was detectable in colorectal tumor patients and patients with early or pre-neoplastic lesions, but not in healthy volunteers. PMID: 15068392

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族:
    Tomoregulin family
  • 組織特異性:
    Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of nor
  • 數據庫鏈接:

    HGNC: 11867

    OMIM: 605734

    KEGG: hsa:23671

    STRING: 9606.ENSP00000272771

    UniGene: Hs.144513



主站蜘蛛池模板: 亚洲狠狠婷婷综合久久蜜芽| 国产精品美女久久久久av超清| 亚洲精品天堂成人片av在线播放| 女人被狂躁c到高潮| 日本妇人成熟免费视频| 午夜爱爱爱爱爽爽爽网站 | 狠狠色婷婷久久综合频道毛片| 国产精品99久久免费黑人人妻| 中国性少妇内射xxxx狠干| 亚洲不卡一卡2卡三卡4卡5卡| 内射人妻无码色ab麻豆| 玩弄少妇人妻| 成人亚洲欧美一区二区三区| 亚洲 日韩 国产 有码 不卡| 国产精品人成视频免费播放| 狠狠色噜噜狠狠狠狠777米奇| 中文字幕无码日韩专区| 牲交a欧美牲交aⅴ免费一| 国产suv精品一区二区33| 又污又爽又黄的网站| 亚洲成av大片大片在线播放| a毛片终身免费观看网站| 国产女人被狂躁到高潮小说| 国产精品久久久久久成人影院| 中文字幕亂倫免賛視頻| 色视频www在线播放国产人成| 99re热视频这里只精品| 亚洲欧美精品综合在线观看| 很黄很黄的曰批视频| 精品无码一区二区三区| 亚洲国产一卡2卡3卡4卡5公司| 国产日韩精品视频无码| 国产精品久久久久久人妻精品动漫| 国产精品交换| 国产成人最新三级在线视频| 最新精品国偷自产在线美女足| 欧美人与动牲交a欧美精品| 国产国产久热这里只有精品| 色偷偷女人的天堂亚洲网| 无套内内射视频网站| 中国性少妇内射xxxx狠干|