在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TMED10 Antibody

  • 中文名稱:
    TMED10兔多克隆抗體
  • 貨號:
    CSB-PA023655GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    TMED10; TMP21; Transmembrane emp24 domain-containing protein 10; Protein TMED10; 21 kDa transmembrane-trafficking protein; S31I125; S31III125; Tmp-21-I; Transmembrane protein Tmp21; p23; p24 family protein delta-1; p24delta1; p24delta
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TMED10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5. In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2. On Golgi membranes, acts as primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization. In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC. Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9. Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40.
  • 基因功能參考文獻:
    1. Low TMED10 expression is associated with breast cancer. PMID: 28115518
    2. TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy, which may be associated with activation of AMPK/mTOR pathway. PMID: 26617795
    3. Study demonstrates that NleF binds to the human Tmp21 protein and subsequently disrupts intracellular protein trafficking. PMID: 23434013
    4. This study suggested that The role ofTMP21 in the modulation of gamma-secretase activity and protein trafficking and related to alzheimer disease. PMID: 22299712
    5. Data show that the level of p23 expression is critical for neuronal function, and p23 overexpression initiates a cascade in brainstem that leads to severe motor deficits and other neurological problems, culminating in premature death. PMID: 22204304
    6. Results suggest that Tmp21 is a novel protein that preferentially binds to Beta(2)-microglobulin-free MHC-I heavy chains. PMID: 21699748
    7. p23 acts as an anchoring protein that retains PKCdelta at the perinuclear region, thus limiting the availability of this kinase for activation in response to stimuli. PMID: 21454541
    8. Transmembrane protein 23 and p24A differentially control G-protein coupled receptor trafficking and signaling in astrocytes. PMID: 21219331
    9. These results demonstrate that p23/Tmp21 acts as an anchor that distinctively modulates compartmentalization of C1 domain-containing proteins, and it plays an essential role in beta2-chimaerin relocalization. PMID: 20164256
    10. TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity PMID: 16641999
    11. TMP21 behaves as a regulator of gamma- but not epsilon-cleavages of beta-amyloid precursor protein generated by presenilin-dependent gamma-secretase complex. PMID: 18405662
    12. p23 is widely distributed throughout the frontal cortex, hippocampus and cerebellum of control and Alzheimer disease (AD)brains; steady-state p23 levels are reduced in the brains of individuals with AD. PMID: 18652896
    13. Taken together, these results indicate that the degradation of TMP21, as with the other presenilin-associated gamma-secretase complex members, is mediated by the ubiquitin-proteasome pathway. PMID: 19046380
    14. the TMP21 transmembrane domain promotes its association with the presenilin complex that results in decreased gamma-cleavage activity PMID: 19710022

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Melanosome.
  • 蛋白家族:
    EMP24/GP25L family
  • 數據庫鏈接:

    HGNC: 16998

    OMIM: 605406

    KEGG: hsa:10972

    STRING: 9606.ENSP00000303145

    UniGene: Hs.74137



主站蜘蛛池模板: 国产 在线 | 日韩| 精品三级久久久久电影网| 国产做爰xxxⅹ久久久精华液| 成人综合伊人五月婷久久| 人与禽交av在线播放| 看国产一毛片在线看手机看| 国产在线视频一区二区三区98 | 久久久久欧美精品观看| 精品动漫一区二区无遮挡| 99香蕉国产精品偷在线观看| 日韩精品无码一区二区| 天堂а√在线最新版中文| 亚洲麻豆av成本人无码网站| 成人伊人青草久久综合网| 国产精品水嫩水嫩| 免费观看又污又黄在线观看| 在线不卡av片免费观看| 国产综合久久久久久鬼色| 国产av无码专区国产乱码| 人人爽人人爽人人片a| 国产原创av中文在线观看| 亚洲国产精品无码久久久不卡| 无码高潮爽到爆的喷水视频| 毛片tv网站无套内射tv网站| 开心色婷婷色五月激情| 永久免费观看国产裸体美女| 日本sm/羞辱/调教/捆绑视频| 高潮喷吹一区二区在线观看| 无码中出人妻中文字幕av | 国产免费永久精品无码| 欧美 日韩 亚洲 在线| 五月色婷婷丁香无码三级 | 日本熟妇浓毛hdsex| 国产午夜亚洲精品不卡| 久久久久人妻精品区一三寸| 人妻少妇偷人精品视频| 亚洲爆乳www无码专区| 国内精品久久人妻无码网站| 成人午夜福利视频| 久久久久久国产精品无码超碰| 久久天堂av综合合色蜜桃网|