在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TMC8 Antibody

  • 中文名稱:
    TMC8兔多克隆抗體
  • 貨號:
    CSB-PA007390
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using TMC8 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TMC8
  • 別名:
    TMC8 antibody; EVER2 antibody; EVIN2 antibody; Transmembrane channel-like protein 8 antibody; Epidermodysplasia verruciformis protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human TMC8.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable ion channel.
  • 基因功能參考文獻:
    1. The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype PMID: 28646613
    2. The present study did not show any significant association of the EVER1/2 polymorphisms (rs2290907and rs16970849) with cervical cancer. PMID: 27899077
    3. There were no differences in Ever2 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls. PMID: 27097911
    4. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC tumours that have lost beta-HPV gene expression during progression. PMID: 26126409
    5. TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV. PMID: 26227733
    6. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology. PMID: 25853559
    7. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK. PMID: 25495765
    8. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2. PMID: 23534907
    9. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2+) release, activation of Ano1 and volume regulated LRRC8-related Cl(-) currents. PMID: 25220380
    10. Expression of both EVER1 and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB signaling. PMID: 25378492
    11. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB signaling pathways in keratinocytes. PMID: 24586810
    12. We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV. PMID: 23535066
    13. Ever2 interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis. PMID: 23429285
    14. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4+ and effector memory CD8+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4+ T-cell subsets. PMID: 22903682
    15. EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated PMID: 22761942
    16. study describes the presence of two previously unreported homozygous mutations in the EVER2 gene in two Italian epidermodysplasia verruciformis patients, each of whom have already developed more than 10 non-melanoma skin cancers PMID: 22158547
    17. Data support the involvement of the TMC6/8 region in cervix cancer susceptibility. PMID: 21387292
    18. Results underline the possible relevance of the EVER2/TMC8 single nucleotide polymorphism rs7208422 in influencing susceptibility to beta-papillomaviruses and their oncogenic potential. PMID: 21196704
    19. Mutations in EVER2 are associated with epidermodysplasia verruciformis. PMID: 12426567
    20. study reports a novel nonsense mutation of the TMC8 gene in Brazilian patients with epidermodysplasia verruciformis PMID: 17711520
    21. Genetic variation in the EVER2 gene is associated with squamous cell carcinoma of the skin PMID: 18224692
    22. epidermodysplasia verruciformis in a father and a son with typical histologic and clinical findings that occur in the absence of mutations in EVER1 or EVER2. PMID: 19706093

    顯示更多

    收起更多

  • 相關疾病:
    Epidermodysplasia verruciformis (EV)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMC family
  • 組織特異性:
    Expressed in placenta, prostate and testis.
  • 數據庫鏈接:

    HGNC: 20474

    OMIM: 226400

    KEGG: hsa:147138

    STRING: 9606.ENSP00000325561

    UniGene: Hs.592102



主站蜘蛛池模板: 另类内射国产在线| 人人爽久久久噜噜噜婷婷| 日韩人妻不卡一区二区三区| 无码av永久免费专区麻豆| 天天躁日日躁狠狠躁av麻豆| 波多野结衣在线播放| 97国产精品人妻无码久久久| 另类国产精品一区二区| 欧美性猛交xxxx三人| 午夜一区一品日本| 久久人人爽人人人人片| 亚洲精品久久久久久下一站| 视频在线+欧美十亚洲曰本| 亚洲精品无码久久久影院相关影片| 五月激情婷婷丁香综合基地| 久久久久亚洲精品| 无码国产精品一区二区免费式芒果| 亚洲精品无码一二区a片| 四虎国产精品永久在线无码| 怡红院av亚洲一区二区三区h| 99久久99久久精品国产片| 老司机导航亚洲精品导航| 国产精品自在线一区| 2019日韩中文字幕mv| 久久精品国产亚洲精品| 在线亚洲精品国产一区麻豆| 毛片大全真人在线| 日本高清一区二区三| 国产欧美精品aaaaaa片| 日夜啪啪一区二区三区| 欧美日韩国产中文高清视频| 国产精品美女久久久久av爽李琼| 精品人妻码一区二区三区| 人人做人人爽国产视| 精品无码乱码av| 国产男小鲜肉同志免费| 亚洲va国产va天堂va久久| 国产精品久久福利网站| 国产成+人+综合+亚洲专区| 精品国产成人高清在线观看| 亚洲人成无码网站久久99热国产|