在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TLK1 Antibody

  • 中文名稱:
    TLK1兔多克隆抗體
  • 貨號:
    CSB-PA004303
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using TLK1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TLK1
  • 別名:
    PKU beta antibody; PKU-beta antibody; serine threonine protein kinase antibody; Serine/threonine protein kinase tousled like 1 antibody; Serine/threonine-protein kinase tousled-like 1 antibody; SNARE protein kinase SNAK antibody; Tlk1 antibody; TLK1_HUMAN antibody; Tousled like kinase 1 antibody; Tousled-like kinase 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human TLK1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
  • 基因功能參考文獻:
    1. Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR and Chk1 activation, indicating the existence of a TLK1>NEK1>ATR>Chk1 pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint. PMID: 28426283
    2. Our results suggest that GA-mediated transient modulation of TLK1 activity promotes DNA repair and suppresses radiation cytoxicity in salivary gland cells. PMID: 26855419
    3. TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint PMID: 26860083
    4. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function. PMID: 24598821
    5. Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. PMID: 24376897
    6. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks. PMID: 21647934
    7. Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage. PMID: 21048794
    8. Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage. PMID: 20381954
    9. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases. PMID: 20016786
    10. we show that Chk1 is essential for the suppression of TLK activity after replication block, but that ATR, Chk2 and BRCA1 are dispensable for TLK suppression. PMID: 12955071
    11. Both eIF4E and TLK1B are elevated in breast cancer specimens but not in benign breast specimens from noncancer patients. Degree of TLK1B elevation is correlated with degree of IF4E overexpression. PMID: 14732354
    12. In addition, it could be demonstrated that increasing the Tlk1 activity in HT1080 cells by forced Tlk1 overexpression leads to an increased phosphorylation of endogenous p68. PMID: 15950181
    13. TLK1B promotes the repair of double strand breaks, likely as a consequence of a change in chromatin remodeling capacity that must precede the assembly of repair complexes at the sites of damage PMID: 16156902
    14. Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 triggering DNA repair. PMID: 17054786
    15. Our data suggest that human PKU-beta/TLK1 plays an important role in chromosome integrity via the regulation of myosin II dynamics by phosphorylating MRLC during mitosis. PMID: 18838128

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性:
    Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
  • 數據庫鏈接:

    HGNC: 11841

    OMIM: 608438

    KEGG: hsa:9874

    STRING: 9606.ENSP00000411099

    UniGene: Hs.744917



主站蜘蛛池模板: 国产精品久久无码一区二区三区网| 97夜夜澡人人双人人人喊| 欧美亚洲高清国产| 亚洲人成色777777老人头| 少妇人妻av毛片在线看| 少妇午夜福利一区二区| 女被啪到深处喷水gif动态图 | 狠狠色色综合网站| 精品国产av无码一区二区三区| 自拍区小说区图片区亚洲| 亚洲精品久久yy5099| 高清国产av一区二区三区| 四虎国产精品永久在线观看| 成人免费的视频| 真人做人60分钟啪啪免费看| 国产成人精品精品日本亚洲| 日产精品久久久久久久蜜臀| 亚洲 欧美日韩 综合 国产| 亚洲伊人久久大香线蕉综合图片 | 18处破外女出血在线| 国内野外强奷在线视频| 国产成人无码av一区二区在线观看 | 六月丁香综合在线视频| 国语自产视频在线| 92国产精品午夜福利免费| 国产熟睡乱子伦午夜视频| 麻豆蜜桃av蜜臀av色欲av| 最美女人体内射精一区二区| 青青草视频在线观看| 人妻教师痴汉电车波多野结衣| 浪荡女天天不停挨cao日常视频| av性色av久久无码ai换脸| 丰满少妇被猛烈进入无码 | 高清国产一区二区三区在线| 伊人大杳焦在线| 茄子视频国产在线观看| 成人欧美一区二区三区1314| 三上悠亚的av片在线无码| 久久被窝亚洲精品爽爽爽| 亚洲色欲色欲www| 2020每日更新国产精品视频|