TLE3 Antibody
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中文名稱：TLE3兔多克隆抗體
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貨號(hào)：CSB-PA023587GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TLE3
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別名：E(sp1) homolog Drosophila antibody; Enhancer of split groucho 3 antibody; Enhancer of split groucho-like protein 3 antibody; ESG 3 antibody; ESG antibody; ESG3 antibody; FLJ39460 antibody; GRG 3 antibody; GRG3 antibody; HsT18976 antibody; KIAA1547 antibody; TLE 3 antibody; Tle3 antibody; TLE3_HUMAN antibody; Transducin like enhancer of split 3 antibody; Transducin like enhancer of split 3 homolog of Drosophila E(sp1) antibody; Transducin like enhancer protein 3 antibody; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) antibody; Transducin-like enhancer protein 3 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human TLE3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
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基因功能參考文獻(xiàn)：
- Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients. PMID: 28859615
- Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination. PMID: 28689657
- Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
- Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression PMID: 25249007
- induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation PMID: 24444608
- High TLE3 expression predicts a favorable response to taxane containing chemotherapy regimens in ovarian carcinoma. PMID: 22194527
- A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis. PMID: 22050093
- results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development PMID: 18273443
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亞細(xì)胞定位：Nucleus.
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蛋白家族：WD repeat Groucho/TLE family
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組織特異性：Placenta and lung.
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數(shù)據(jù)庫(kù)鏈接：
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