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  4. TIPRL Antibody, Biotin conjugated

TIPRL Antibody, Biotin conjugated

  • 中文名稱：
    TIPRL兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA023569LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TIPRL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TIPRL
  • 別名：
    1810011K17Rik antibody; dJ69E11.3 antibody; MGC3794 antibody; Putative MAPK activating protein PM10 antibody; Putative MAPK-activating protein PM10 antibody; RP1-69E11.1 antibody; Tip antibody; TIP41 antibody; TIP41-like protein antibody; tiprl antibody; TIPRL_HUMAN antibody; TOR signaling pathway regulator antibody; TOR Signaling Pathway Regulator like antibody; Type 2A-interacting protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TIP41-like protein (1-178AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
  • 基因功能參考文獻：
    1. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation PMID: 26717153
    2. Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. PMID: 23892082
    3. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
    4. TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues. PMID: 22841785
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    TIP41 family
  • 數據庫鏈接：

    HGNC: 30231

    OMIM: 611807

    KEGG: hsa:261726

    STRING: 9606.ENSP00000356807

    UniGene: Hs.209431



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