在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TIPIN Antibody

TIPIN Antibody

  • 中文名稱：
    TIPIN兔多克隆抗體
  • 貨號：
    CSB-PA023568GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TIPIN
  • 別名：
    FLJ20516 antibody; TIMELESS interacting protein antibody; TIMELESS-interacting protein antibody; TIPIN antibody; TIPIN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human TIPIN
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
  • 基因功能參考文獻：
    1. the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin. PMID: 28334766
    2. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer. PMID: 26004086
    3. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer DNA ligand. PMID: 23511638
    4. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. PMID: 23359676
    5. We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle. PMID: 21490103
    6. RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1 PMID: 20233725
    7. The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks. PMID: 20124417
    8. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint PMID: 17102137
    9. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells PMID: 17116885
    10. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs. PMID: 17141802
    11. These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA. PMID: 17296725

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSM3 family
  • 數據庫鏈接：

    HGNC: 30750

    OMIM: 610716

    KEGG: hsa:54962

    STRING: 9606.ENSP00000261881

    UniGene: Hs.744308



主站蜘蛛池模板： 亚洲午夜精品a片久久www慈禧| 欧美日产国产精品| 99久久精品无码一区二区三区| 日韩久久无码免费毛片软件| 国产精品人成在线播放新网站| 亚洲欧美日韩成人一区在线| 夜夜春夜夜爽| 中文字幕亚洲乱码熟女在线 | 国产亚洲精品第一综合另类| 丰满熟妇被猛烈进入高清片| 亚洲精品亚洲人成在线| 亚洲欧洲av一区二区久久| 欧美老妇乱辈通奷| 337p日本欧洲亚洲大胆裸体艺术| 精品无码国产自产拍在线观看蜜| 最新69国产成人精品视频| 亚洲另类欧美综合久久图片区| 亚洲精品一区国产精品| 亚洲乱码国产乱码精品精大量| 中文字幕无码精品三级在线电影| 夜夜香夜夜摸夜夜添视频| 国产午夜精品一区二区| 亚洲337少妇裸体艺术| 超级大爆乳奶牛被调教出奶水| 色欲狠狠躁天天躁无码中文字幕| 国产精品永久免费视频| 国产精品亚洲精品一区二区 | 欧美性色黄大片| 肥臀浪妇太爽了快点再快点| 日本毛茸茸的丰满熟妇| 在线 | 国产精品星空传媒丿| 色综合久久蜜芽国产精品| 免费女人高潮流视频在线| 亚洲五月综合缴情在线观看| 成人午夜精品无码区久久| 人妻夜夜爽天天爽| 动漫av纯肉无码免费播放| 中文字幕被公侵犯的漂亮人妻| 老妇肥熟凸凹丰满刺激| 亚洲欧洲自拍拍偷精品网| av无码精品一区二区三区四区 |