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  4. THOC6 Antibody

THOC6 Antibody

  • 中文名稱：
    THOC6兔多克隆抗體
  • 貨號：
    CSB-PA023506GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    THOC6
  • 別名：
    THOC6 antibody; WDR58 antibody; PSEC0006 antibody; THO complex subunit 6 homolog antibody; Functional spliceosome-associated protein 35 antibody; fSAP35 antibody; WD repeat-containing protein 58 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human THOC6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.
  • 基因功能參考文獻：
    1. Results indicate three unrelated patients with bi-allelic mutations in THOC6 associated with intellectual disability and additional clinical features. PMID: 27102954
    2. In addition to confirming the morbid nature of THOC6 by providing an independent homozygous apparently loss of function allele in a patient with a compatible phenotype, our data also expand THOC6-related phenotype to include previously unreported imperforate anus and undescended testicles. PMID: 26739162
  • 相關疾病：
    Beaulieu-Boycott-Innes syndrome (BBIS)
  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    WD repeat THOC6 family
  • 數據庫鏈接：

    HGNC: 28369

    OMIM: 613680

    KEGG: hsa:79228

    STRING: 9606.ENSP00000326531

    UniGene: Hs.412304



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