在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

THOC5 Antibody, Biotin conjugated

  • 中文名稱:
    THOC5兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA613425LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) THOC5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    THOC5
  • 別名:
    C22orf19 antibody; Chromosome 22 open reading frame 19 antibody; Fmip antibody; Fms interacting protein antibody; fSAP79 antibody; Functional spliceosome-associated protein 79 antibody; hTREX90 antibody; KIAA0983 antibody; LOC400922 antibody; NF2/meningioma region protein pK1.3 antibody; PK1.3 antibody; Placental protein 39.2 antibody; PP39.2 antibody; THO complex 5 antibody; THO complex subunit 5 antibody; THO complex subunit 5 homolog antibody; thoc5 antibody; THOC5_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human THO complex subunit 5 homolog protein (2-53AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.; Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
  • 基因功能參考文獻:
    1. Data suggest that the suppression of the multiple THOC5 target genes may represent a novel strategy for hepatocellular carcinoma (HCC) therapy. PMID: 26549021
    2. THOC5 to be a novel gene involved in the regulation of serum HDL-C levels PMID: 24023261
    3. Authors suggest a model in which human Thoc5 controls polyadenylation site choice through the co-transcriptional loading of CFIm68 onto target genes. PMID: 23685434
    4. show that THOC5 Y225 phosphorylation governs mRNA binding. In addition, CXCL12 is shown to induce THOC5 Y225 phosphorylation, and site-directed mutagenesis demonstrates that this modulates motile response PMID: 23032722
    5. show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation PMID: 21937706
    6. THOC5 protein expression can potentiate receptor signalling to transcription factor expression and monocyte differentiation. PMID: 19015024
    7. THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. PMID: 19059247
    8. Thoc5 exhibits in vitro RNA-binding activity and is associated with HSP70 mRNPs in vivo as a component of the stable THO complex PMID: 19165146

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    THOC5 family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 19074

    OMIM: 612733

    KEGG: hsa:8563

    STRING: 9606.ENSP00000380969

    UniGene: Hs.75361



主站蜘蛛池模板: 麻豆av一区二区三区| 日本三级在线播放线观看视频| 99国产精品久久久久久久久久久| 久久精品人妻无码一区二区三区 | 小嫩妇好紧好爽再快视频| 性色欲情网站| 久久久国产精品无码一区二区| 深夜福利小视频在线观看| 国产麻豆md传媒视频| 狠狠色成人综合网| 无码精品人妻一区二区三区av| 99无码熟妇丰满人妻啪啪| 国内精品国产成人国产三级| 77777五月色婷婷丁香视频| 欧美成人高清视频a在线看| 欧洲美熟女乱又伦| 国产人妻人伦精品1国产| 扒开双腿猛进入喷水高潮叫声| 老子影院午夜伦手机不四虎卡| 性欧美暴力猛交69hd| 日韩欧美中文字幕在线三区| 永久免费精品成人网站| 精品无码国产污污污免费| 国产乱妇无乱码大黄aa片| 越猛烈欧美xx00动态图| 亚洲欧洲日本综合aⅴ在线 | 日本天天日噜噜噜| 伊人久久大香线蕉影院| 欧美人妻aⅴ中文字幕 | 国产综合久久久久| 99精品热这里只有精品| 亚洲色成人影院在线观看| 久久久精品国产免大香伊| 男女免费观看做爰视频在线观看 | 精品国产肉丝袜久久| 粗大的内捧猛烈进出在线视频| 狂野欧美性猛xxxx乱大交| 成人午夜福利院在线观看| 欧美性黑人极品hd| 国产亚洲精品久久久久久| 2020精品国产视|