在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. THOC1 Antibody

THOC1 Antibody

  • 中文名稱：
    THOC1兔多克隆抗體
  • 貨號：
    CSB-PA023501GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    THOC1
  • 別名：
    hTREX84 antibody; Death domain containing protein p84N5 antibody; HPR 1 antibody; HPR1 antibody; hTREX84 antibody; Nuclear matrix protein p84 antibody; P84 antibody; p84N5 antibody; Tho 1 antibody; THO complex 1 antibody; THO complex subunit 1 antibody; Tho1 antibody; THOC 1 antibody; Thoc1 antibody; THOC1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human THOC1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
  • 基因功能參考文獻：
    1. THO interacts with the Sin3A histone deacetylase complex to suppress co-transcriptional R-loops, DNA damage, and replication impairment. Functional analyses show that histone hypo-acetylation prevents accumulation of harmful R-loops and RNA-mediated genomic instability. PMID: 29074626
    2. Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer. PMID: 26545775
    3. In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment. PMID: 25296641
    4. Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells. PMID: 24682263
    5. This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity. PMID: 23460917
    6. overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 PMID: 22952718
    7. We show that human THO depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX and 53BP1 foci accumulation PMID: 22144908
    8. A differential connection between tumorogenesis and the expression levels of human THO and ALY. PMID: 21329510
    9. hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors PMID: 15870275
    10. recruitment of the human TREX complex to spliced mRNA is not directly coupled to transcription, but is instead coupled to transcription indirectly through splicing PMID: 15998806
    11. Thoc1 may be important for neoplastic transformation PMID: 17638875
    12. Cells respond to AAV infection by activating two DNA damage signaling cascades. The first activates the p84N5 protein, which in turn activates caspase-6, leading to cell death. PMID: 17699767
    13. elevated expression of hHpr1/p84/Thoc1 is common in NSCLC and may have prognostic significance in subgroups of patients PMID: 18469354

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.; [Isoform 2]: Cytoplasm.
  • 組織特異性：
    Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correl
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19070

    OMIM: 606930

    KEGG: hsa:9984

    STRING: 9606.ENSP00000261600

    UniGene: Hs.712543



主站蜘蛛池模板： 中文字幕va一区二区三区| 日本真人做爰免费的视频| 台湾佬中文娱乐22vvvv| 国产亚洲精品第一综合不卡 | 日韩欧美偷拍高跟鞋精品一区| 国产精品 欧美 亚洲 制服 | 2020无码专区人妻系列日韩| 亚洲精品国产嫩草在线观看东京热| 97国产超碰一区二区三区| 国产专区免费资源网站| 色窝窝无码一区二区三区成人网站| 成人麻豆日韩在无码视频| 美女粉嫩饱满的一线天mp4| 无人区乱码区1卡2卡三卡网站| 天堂а√在线最新版中文在线| 国产av夜夜欢一区二区三区| 国产精品欧美成人片| 伦埋琪琪久久影院三级| 国产98色在线 | 国产| 日产精品卡二卡三卡四卡乱码视频| 亚洲色在线无码国产精品| 久久久综合九色合综| 国产亚洲精品久久久久婷婷瑜伽| 少妇被躁爽到高潮| 日韩亚洲国产综合高清| 欧美日韩在大午夜爽爽影院| 男女裸交免费无遮挡全过程| 国产在热线精品视频99公交| 亚洲国产丝袜精品一区| 欧洲精品99毛片免费高清观看| 无码精品国产dvd在线观看9久| 亚洲综合无码av一区二区三区 | 免费欧洲美女牲交视频| 狠狠躁夜夜躁人人爽蜜桃| 四库影院永久国产精品地址 | 久久综合久久美利坚合众国| 99精品热在线在线观看视频| av无码欧洲亚洲电影网| 亚洲已满18点击进入在线看片| 色综合视频一区中文字幕| 亚洲性无码av在线dvd|