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  4. THEMIS Antibody, Biotin conjugated

THEMIS Antibody, Biotin conjugated

  • 中文名稱：
    THEMIS兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA850780LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) THEMIS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    THEMIS
  • 別名：
    C6orf190 antibody; C6orf207 antibody; MGC163388 antibody; Protein THEMIS antibody; SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody; SPOT antibody; THEMIS antibody; THMS1_HUMAN antibody; Thymocyte expressed molecule involved in selection antibody; Thymocyte selection associated antibody; Thymocyte selection pathway associated antibody; Thymocyte-expressed molecule involved in selection antibody; TSEPA antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein THEMIS protein (547-641AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
  • 基因功能參考文獻：
    1. we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms PMID: 27438997
    2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. PMID: 28250424
    3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival. PMID: 25535246
    4. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls. PMID: 23820479
    5. THEMIS binding to GRB2 was required for thymocyte development. PMID: 23460737
    6. Themis1 exhibits the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice. PMID: 22732588
    7. SPOP mutations may define a new molecular subtype of prostate cancer. PMID: 22610119
    8. specific role for THEMIS in early TCR signalosome function PMID: 21189249
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    11. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20095854
    12. Functional characterization of the homologous mouse gene. PMID: 19597498
    13. Functional analysis of the mouse gene by knockout, and comparison of the mouse and human proteins. PMID: 19597499

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Themis family
  • 數據庫鏈接：

    HGNC: 21569

    OMIM: 613607

    KEGG: hsa:387357

    UniGene: Hs.661756



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