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THADA Antibody

  • 中文名稱：
    THADA兔多克隆抗體
  • 貨號：
    CSB-PA751092ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA751092ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) THADA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    THADA
  • 別名：
    THADA antibody; GITA antibody; KIAA1767 antibody; Thyroid adenoma-associated protein antibody; Gene inducing thyroid adenomas protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Thyroid adenoma-associated protein (1684-1953AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn)：
    1. THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. PMID: 28193878
    2. this identifies THADA as a regulator of the balance between energy consumption and energy storage, which was selected during human evolution. PMID: 28399403
    3. association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
    4. Our results showed that rs1465618 in THADA may be a shared susceptibility variant for PCa in multiple populations. PMID: 24685913
    5. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample. PMID: 23512105
    6. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight. PMID: 23349771
    7. DNA methylation of genes in retinol metabolism and calcium signaling pathways (P < 3 x 10-6) and with known functions in muscle and T2D including MEF2A, RUNX1, NDUFC2, and THADA decreased after exercise PMID: 23028138
    8. identification of the target gene of 2p21 aberrations in thyroid adenomas tentatively referred to as thyroid adenoma-associated gene (THADA); gene spans roughly 365 kbp; based on preliminary results, it encodes a death receptor-interacting protein [THADA] PMID: 12955091
    9. intronic sequence of PPAR(gamma) is fused to exon 28 of THADA in thyroid tumors of follicular origin including carcinomas as well as adenomas PMID: 17123335

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  • 相關(guān)疾病：
    Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.
  • 蛋白家族：
    THADA family
  • 組織特異性：
    Expressed in pancreas, adrenal medulla, thyroid, adrenal cortex, testis, thymus, small intestine and stomach.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19217

    OMIM: 611800

    KEGG: hsa:63892

    STRING: 9606.ENSP00000385995

    UniGene: Hs.369592



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