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  4. TGM6 Antibody

TGM6 Antibody

  • 中文名稱：
    TGM6兔多克隆抗體
  • 貨號：
    CSB-PA577486
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA577486(TGM6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TGM6
  • 別名：
    Protein-glutamine gamma-glutamyltransferase 6 antibody; TG6 antibody; TGase Y antibody; TGase-3-like antibody; TGase-6 antibody; TGM3L_HUMAN antibody; TGM6 antibody; TGY antibody; Transglutaminase 6 antibody; Transglutaminase Y antibody; Transglutaminase-3-like antibody; Transglutaminase-6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human TGM6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
  • 基因功能參考文獻：
    1. Results indicate that mutations differently impacting on TG6 function cause neuronal dysfunction and death through diverse mechanisms. PMID: 28934387
    2. TGM6 missense mutation cosegregated with AML in a large family. PMID: 24755948
    3. Two missense mutations (p.R111C and p.D510H) and one 3-base pair deletion (p.E574del) in TGM6 were identified in Spinocerebellar ataxia 35. PMID: 25253745
    4. Whole-exome and targeted sequencing have defined the genetic basis of dizziness including new genes causing ataxia: GBA2, TGM6, ANO10 and SYT14 PMID: 24275721
    5. transglutaminase 6 could be involved in polyQ diseases. PMID: 23800413
    6. Results indicate a mutation in the transglutaminase 6 (TGM6) gene (c.1528G>C) which showed co-segregation with disease phenotype in all nine members of this family. PMID: 22554020
    7. Antibodies against TG6 are gluten-dependent and appear to be a sensitive and specific marker of glten ataxia. PMID: 23576621
    8. this study analyzed the subcellular distribution, expression and in vitro activity of two missense mutations of TG6 (D327G, L517W) and found that both mutants exhibited decreased transglutaminase activity and stability. PMID: 23206699
    9. Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. PMID: 21939789
    10. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing TMG6 genes causing ataxia. PMID: 22527681
    11. TG6 autoantibodies are not gluten-dependent PMID: 21453693
    12. findings lend credence to the notion that TG3 and TG6 are involved in the gluten-induced autoimmune responses of dermatitis herpetiformis and gluten ataxia PMID: 20300788
    13. The finding of TGM6 as a novel causative gene of spinocerebellar ataxia illustrates whole-exome sequencing of affected individuals from one family PMID: 21106500
    14. Antibodies against transglutaminase 6 can serve as marker antibodies to identify a subgroup of patients with gluten sensitivity who may be at risk for development of neurological disease. PMID: 18825674

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  • 相關疾病：
    Spinocerebellar ataxia 35 (SCA35)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Transglutaminase superfamily, Transglutaminase family
  • 數據庫鏈接：

    HGNC: 16255

    OMIM: 613900

    KEGG: hsa:343641

    STRING: 9606.ENSP00000202625

    UniGene: Hs.452039



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