在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TGFBR3 Antibody

  • 中文名稱:
    TGFBR3兔多克隆抗體
  • 貨號:
    CSB-PA023453GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TGFBR3
  • 別名:
    Beta glycan antibody; Betaglycan antibody; Betaglycan proteoglycan antibody; BGCAN antibody; TGBR3_HUMAN antibody; TGF beta receptor type 3 antibody; TGF beta receptor type III antibody; TGF-beta receptor type 3 antibody; TGF-beta receptor type III antibody; TGFB R3 antibody; TGFBR 3 antibody; TGFBR3 antibody; TGFR 3 antibody; TGFR-3 antibody; TGFR3 antibody; Transforming growth factor beta receptor III antibody; Transforming growth factor beta receptor III betaglycan 300kDa antibody; Transforming growth factor beta receptor type 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human TGFBR3-Specific
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
  • 基因功能參考文獻:
    1. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells PMID: 29050936
    2. TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas. PMID: 26980036
    3. opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, likely via Wnt sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a signaling. PMID: 27784788
    4. Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization. PMID: 27628954
    5. Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC) progression leading to the activation of Smad2 and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC, by inhibiting Smad2 and Akt pathways. PMID: 26882862
    6. Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression. PMID: 26531330
    7. No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium. PMID: 26548418
    8. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
    9. Data suggest a high potential of plasma sTBFbetarIII as a novel diagnostic and prognostic biomarker in breast cancer. PMID: 26190421
    10. rs1192415 of TGFBR3 is associated with primary open angle glaucoma. PMID: 25861811
    11. The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients. PMID: 26383992
    12. Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness and abrogated TbetaRIII's ability to inhibit breast cancer cell migration and invasion. PMID: 24966170
    13. RS1805110 is not associated with Behcet's disease or idiopathic intermediate uveitis in Caucasian patients. PMID: 25677673
    14. data suggest complex or phenotype specific association of cryptorchidism with TGFBR3 and the gubernaculum as a potential target of TGFbeta signaling PMID: 25390077
    15. We have found that TbetaRIII is required for migration and invasion in vitro and xenograft growth in vivo. PMID: 24985072
    16. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. PMID: 25077702
    17. Proper localization of TGFBRIII is critical for maintenance of epithelial cell polarity and phenotype. PMID: 24870032
    18. TGFBR3 co-downregulated with GATA3 is associated with methylation of the GATA3 gene in bladder urothelial carcinoma. PMID: 24124001
    19. Report the presence of TGFBR3 and/or MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms. PMID: 24705316
    20. Therefore transient overexpression of TGFBR3 may be a novel strategy for nasopharyngeal carcinoma prevention and therapy PMID: 23387308
    21. Low TGFBR3 expression is associated with bladder urothelial carcinoma and enhanced in the invasive bladder cancer. PMID: 23835618
    22. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
    23. TbetaRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TbetaRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK. PMID: 24216509
    24. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TbetaRIII in maintaining acinar organization in the breast. PMID: 23226100
    25. Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways. PMID: 22562249
    26. Polymorphisms in the betaglycan gene, a co-receptor mediating functional antagonism of activin signalling, significantly predict antidepressant drug treatment outcome in a system-wide pharmacogenetics study in depression. PMID: 23092981
    27. a differential regulation of Smads and TGF-beta receptors PMID: 22927969
    28. Variations in TGFBR3 gene appear not to be associated with Marfan syndrome or related phenotype. PMID: 22300218
    29. Novel missense mutations in the TGFBR3 gene are associated with premature ovarian failure in Chinese women. PMID: 22036907
    30. rs1805110 CC genotype in TGFBR3 is probably associated with the protection from BD. The tested two TGFBR3 SNPs are not associated with VKH disease. PMID: 22440163
    31. TGFBR3 mutations may be responsible for the genetic aetiology of idiopathic premature ovarian failure in Chinese patients. PMID: 21756058
    32. Markers located in the region of TGFBR3 and BMP7 showed association with all testicular dysgenesis syndrome phenotypes in both the discovery and replication cohorts PMID: 22140272
    33. TGFBR3 polymorphisms and its haplotypes might be associated with hepatitis B virus clearance and age of hepatocellular carcinoma occurrence. PMID: 21829018
    34. Chromosomal translocation t(1;10) is consistent with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. PMID: 21717526
    35. These data support a model whereby TbetaRIII mediates TGF-beta superfamily ligand-induced colon cancer progression and support a context-dependent role for TbetaRIII in regulating cancer progression. PMID: 21847367
    36. type III transforming growth factor-beta protein expression is decreased in human multiple myeloma specimens. PMID: 21411633
    37. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
    38. endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFbeta2-induced signaling. PMID: 21261473
    39. TGFBR3 is associated with acute lung injury in mice PMID: 21297076
    40. Association of genetic variants in TGFBR3 and asthma in a Korean population. PMID: 20386084
    41. Reduced expression of TGFBR3 was observed in non-small cell lung cancer(NSCLC) cell lines, especially in 95D, suggesting that TGFBR3 might play an important role in development and progression of NSCLC. PMID: 20677641
    42. Use of sucrose-density ultracentrifugation to isolate membrane-raft fractions demonstrates recruitment of both TGFBbeta receptor (TGFbetaR)II and TGFbetaRI to non-raft membrane fractions by TGFbetaRIII. PMID: 20406198
    43. Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. PMID: 20208565
    44. report demonstrates the aberrantly increased expression of betaglycan mRNA in polycystic ovary syndrome ovaries; mechanism by which betaglycan contributes to the pathologic process of PCOS remains to be clarified PMID: 20178540
    45. A review on the role of TbetaRIII as a suppressor of cancer progression and/or as a metastasis suppressor. PMID: 20153821
    46. Partial plasmin digestion of soluble betaglycan produces two proteolysis-resistant fragments of 45 and 55 kilodaltons (kDa) corresponding, respectively, to betaglucan membrane-distal and -proximal regions. PMID: 19842711
    47. endoglin and betaglycan have a critical role in the regulation of TGFbeta signaling in chondrocytes PMID: 12568406
    48. Results quantify the relative expression of inhibin alpha, inhibin/activin beta(A), beta(B), beta(C), follistatin, activin receptors and beta-glycan genes in placental tissue of term pre-eclamptic patients. PMID: 12651901
    49. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
    50. findings indicate a physiologically significant, unanticipated role for beta arrestin 2 in regulating TGF-beta signaling through internalization and subsequent decreased signaling of TGF-beta receptors PMID: 12958365

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
  • 數據庫鏈接:

    HGNC: 11774

    OMIM: 600742

    KEGG: hsa:7049

    STRING: 9606.ENSP00000212355

    UniGene: Hs.482390



主站蜘蛛池模板: 成 人影片 aⅴ毛片免费观看 | 热re99久久精品国产66热| 免费裸体黄网站18禁免费 | 欧美丰满熟妇xxxx| 醉酒后少妇被疯狂内射视频 | 国产初高中生真实在线视频| 啪啪无码人妻丰满熟妇| 國产一二三内射在线看片 | 男人j桶进女人p无遮挡免费观看 | 韩国精品一区二区三区四区| 免费无码成人av电影在线播放 | 无套内射在线观看theporn| 成人精品一区日本无码网| 中文字幕乱码人妻二区三区| 免费视频爱爱太爽了| 国产高清精品软件丝瓜软件| 果冻传媒18禁免费视频| 亚洲一区精品二人人爽久久| 无码人妻精品一区二区三 | 爱久久av一区二区三区| 少妇人妻偷人精品视蜜桃| 国产一区二区野外| 免费能直接看黄的视频| 国产精品无码a∨麻豆| 欧美 日韩 国产 亚洲 色| 婷婷四房色播| 波多野结衣爽到高潮大喷| 四虎影库久免费视频| 狠狠噜天天噜日日噜| 成人网站免费观看入口| 国内精品免费久久久久软件| 亚洲欧美中文字幕高清在线| 免费拍拍拍网站| 女人和拘做爰正片视频| 日韩国产亚洲欧美中国v| 免费精品国偷自产在线2020| 亚洲aⅴ无码专区在线观看q| 波多野吉衣av无码| 国产精品黄页免费高清在线观看| 欧美肥臀大屁股magnet| 色欲香天天天综合网站|