在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TGFB1I1 Antibody

  • 中文名稱:
    TGFB1I1兔多克隆抗體
  • 貨號:
    CSB-PA932436
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HEPG2 cells using Hic-5 Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TGFB1I1
  • 別名:
    Androgen receptor coactivator 55 kDa protein antibody; Androgen receptor coactivator ARA55 antibody; Androgen receptor-associated protein of 55 kDa antibody; ARA55 antibody; Hic-5 antibody; Hydrogen peroxide-inducible clone 5 protein antibody; Tgfb1i1 antibody; TGFI1_HUMAN antibody; Transforming growth factor beta 1 induced transcript 1 antibody; Transforming growth factor beta-1-induced transcript 1 protein antibody; TSC 5 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Hic-5 at AA range: 291-340
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
  • 基因功能參考文獻:
    1. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5 PMID: 28612841
    2. Here we show genome-wide that blocked GBR generally require CHD9 and BRM for GR occupancy in contrast to GBR that are not blocked by Hic-5. Hic-5 blocked GBR are enriched near Hic-5 blocked GR target genes but not near GR target genes that are not blocked by Hic-5. PMID: 29738565
    3. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior PMID: 27893716
    4. Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor. PMID: 28381557
    5. As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR) signal pathway, then constituting a more feasible environment to cancer cells. PMID: 27178620
    6. Hic-5 appears to enhance complex formation between MT1-MMP and FAK in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility. PMID: 26769900
    7. Hic-5 plays a central role in the positive feedback ROS-JNK signaling cascade that regulates hepatocellular carcinoma progression. PMID: 26416447
    8. Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation. PMID: 25763609
    9. Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis. PMID: 25587044
    10. Studies in vitro and in vivo using TGF-beta1 and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta stimulated EMT that contributes to malignant progression of astrocytomas. PMID: 25333259
    11. Hic-5 siRNA also suppressed TGF-beta2-induced fibrogenic activity and dexamethasone-induced myocilin expression in HTM cells. PMID: 26313302
    12. Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment. PMID: 24440747
    13. Hic-5 suppresses senescence and profibrotic activities of myofibroblasts by down-regulating Nox4 expression. PMID: 24831009
    14. The ubiquitin ligase activity of Cbl-c by the direct interaction of the LIM zinc coordinating domain of Hic5 is demonstrated. PMID: 23145173
    15. Hic-5 can potentially exercise multiple functions in growth, differentiation, migration and adhesion of keratinocytes, partially via nuclear-cell membrane shuttling. PMID: 23062781
    16. the HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss PMID: 23007394
    17. It plays a roll in extracellular matrix remodeling and the signal transduction via reactive oxygen species. (review) PMID: 22712231
    18. Findings suggest that hydrogen peroxide-inducible clone-5 (Hic-5) is involved in changes in the mesangial cells (MCs) phenotype to produce abnormal extracellular matrix remodeling in glomerulonephritis (GN). PMID: 22286178
    19. these results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway. PMID: 21996749
    20. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
    21. Hic-5 is essential for adhesion formation in 3D extracellular matrices. PMID: 21148292
    22. Hic-5/ARA55 expression in response to castration-enabled epithelial regression through the repression of c-myc gene at the chromatin level. PMID: 20818421
    23. Hic-5/ARA55 has roles in keloids through Smad pathway and profibrotic transcription PMID: 20395114
    24. Hydrogen peroxide-inducible clone 5 is expressed predominantly in pyramidal neurons of human hippocampus. PMID: 20448481
    25. coregulator of androgen receptor coativation, suppresssed by Pyk2 PMID: 11856738
    26. that hic-5 plays a role in the initial stage of myogenic differentiation. PMID: 11937715
    27. Results suggest that paxillin and Hic-5 associate with GIT1 with different binding modes. PMID: 12153727
    28. a key element in the transduction of signals from the cell surface to the nucleus under oxidative stress-review PMID: 12400158
    29. results suggest that Hic-5 participates in the transcriptional regulation of c-fos as a scaffold in transcriptional complexes. PMID: 12445807
    30. Results show that Hic-5 accumulates in the nucleus in response to oxidants such as hydrogen peroxide PMID: 12631731
    31. Higher ARA55 expression may result in unfavorable recurrence-free survival and overall survival in hormone-refractory prostate cancer PMID: 12858356
    32. the C terminus of ARA55 is critical for suppression of Smad3 activity PMID: 15561701
    33. Hic-5/ARA55 is required for optimal GR-mediated gene expression possibly by providing a scaffold that organizes or stabilizes coactivator complexes at some hormone-responsive promoters. PMID: 16141357
    34. human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5 PMID: 16624805
    35. Small interfering RNA ablation experiments established endogenous Hic-5/ARA55 as a coactivator for both viral and endogenous cellular AR-regulated genes. PMID: 16849583
    36. Review highlights the role that Hic-5 may play in regulating androgen-induced growth factor signaling and/or cytokine expression in the prostate. PMID: 17166536
    37. Hic-5/ARA55 is a molecular regulator for androgen sensitivity in human hair follicles. PMID: 17508020
    38. The increased expression of ARA55 is a feature of nonobstructive azoospermia. PMID: 17919607
    39. Silencing Hic-5 in hypertrophic scar fibroblasts reduces TGF-beta1 production, decreases generation of supermature focal adhesions, reduces expression of smooth-muscle cell alpha-actin and decreases collagen contraction and extracellular matrix synthesis. PMID: 18401422
    40. The level of Smad7 is modulated by its physical interaction with Hic-5 and targeted to a degradation pathway not likely to be proteasomal PMID: 18762808
    41. The data suggest that the proposed progesterone resistance in endometrium from women with endometriosis derives, in part, from impaired expression of the PR coactivator, Hic-5, in endometrial tissue and cultured endometrial stromal fibroblasts. PMID: 19389829

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
  • 蛋白家族:
    Paxillin family
  • 組織特異性:
    Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11767

    OMIM: 602353

    KEGG: hsa:7041

    STRING: 9606.ENSP00000378332

    UniGene: Hs.513530



主站蜘蛛池模板: 色妺妺免费影院| 久久精品超碰av无码| 国内精品视频一区二区八戒| 国产成人三级在线视频网站观看| 天天爱天天做狠狠久久做| 好男人社区资源| 国产成人综合久久三区| 日本中文字幕一区二区有码在线| 日本三级在线播放线观看视频| 中国精学生妹品射精久久| 久久av一区二区三区| 狠狠精品干练久久久无码中文字幕| 医院人妻闷声隔着帘子被中出| 无码av岛国片在线播放| 欧美巨大黑人精品videos| 东京热无码av一区二区| 人与动人物xxxx毛片人与狍| 欧美成人精品福利视频| 春药高潮抽搐流白浆在线观看| 国产午夜成人免费看片app| 久久国语露脸国产精品电影| www片香蕉内射在线88av8| 中无码人妻丰满熟妇啪啪| 国产婷婷丁香五月缴情成人网| 男女啪啪永久免费网站| 无码成人aaaaa毛片| 国产精品videossex久久发布 | 亚洲成av人片在线观l看福利1| 亚洲中久无码永久在线观看同| 天天摸夜夜摸夜夜狠狠摸| 日产幕无线码三区在线| 国产成人精品精品日本亚洲| 欧美交换国产一区内射| 99亚洲男女激情在线观看 | 少女韩国电视剧在线观看完整| 欧美日韩人人模人人爽人人喊| 中字幕久久久人妻熟女天美传媒 | 少女韩国电视剧在线观看完整 | 欧美一区二区三区性视频| 无遮挡很爽很污很黄的网站| 亚洲日韩精品a∨片无码|