在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFG Antibody

  • 中文名稱:
    TFG兔多克隆抗體
  • 貨號:
    CSB-PA023434GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TFG
  • 別名:
    FLJ36137 antibody; HMSNP antibody; OTTHUMP00000214045 antibody; OTTHUMP00000214046 antibody; OTTHUMP00000214047 antibody; OTTHUMP00000214048 antibody; Protein TFG antibody; SPG57 antibody; TF6 antibody; TFG antibody; TFG_HUMAN antibody; TRK fused antibody; TRK fused gene antibody; TRK fused gene protein antibody; TRK-fused gene protein antibody; TRKT3 antibody; TRKT3 oncogene antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TFG
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
  • 基因功能參考文獻:
    1. Differences in the severity of the disorder as well as new clinical findings. These include presence of clonus, undeveloped speech, and sleep disturbances. these findings extend the phenotypic spectrum associated with the TFG mutations in Hereditary spastic paraplegia. PMID: 28124177
    2. TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. PMID: 27184855
    3. Results identified two TFG variants associated with hereditary spastic paraplegias (HSP) (c.316C>T and c.317G> A) confirming the causal nature of bi-allelic TFG mutations for HSP, and suggest that that mitochondrial impairment represents a pathomechanistic link to other neurodegenerative conditions. PMID: 27492651
    4. We established a genetic diagnosis in six families with autosomal recessive HSP (SPG11 in three families and TFG/SPG57, SACS and ALS2 in one family each). A heterozygous mutation in a gene involved in an autosomal dominant HSP (ATL1/SPG3A) was also identified in one additional family. Six out of seven identified variants were novel. PMID: 27601211
    5. This study finding p.Gly269Val in a newly identified Iranian pedigree affected with hereditary motor and sensory neuropathy with proximal predominance. PMID: 27653917
    6. HMSN-P caused by p.Pro285Leu mutation in TFG is not confined to patients with Far East ancestry. PMID: 25725944
    7. TFG functions at the endoplasmic reticulum (ER)/ER-Golgi intermediate compartments (ERGIC) interface to locally concentrate COPII-coated transport carriers and link exit sites on the ER to ERGIC membranes. PMID: 25586378
    8. TRIM68 targets TFG, a novel regulator of IFN production, and in doing so turns off and limits type I IFN production in response to anti-viral detection systems PMID: 24999993
    9. TFG plays an important role in the protein secretory pathways that are essential for proper functioning of the human peripheral nervous system. PMID: 25098539
    10. Study demonstrates that TFG1 physiologically functions to inhibit the protein degradation system, resulting in an increase in ER resident proteins and ER stress; the P285L mutant substantially enhances these consequences PMID: 24613659
    11. TFG plays a pivotal role in negative regulation of RNA-sensing, RIG-I-like receptor (RLR) family signaling pathways. PMID: 23810392
    12. Whole-exome sequencing reveals that HMSN-P is caused by a mutation in the TRK-fused gene on chromosome 3q13.2 PMID: 23553329
    13. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. PMID: 23479643
    14. results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product PMID: 22581839
    15. The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement. PMID: 22883144
    16. Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma. PMID: 22250051
    17. A polymorphic gene fusion consisting of TRK-fused gene and G-protein-coupled receptor 128 is identified in healthy individuals and in patients with lymphoma and soft tissue neoplasms. PMID: 19797732
    18. TFG was fused to NOR1 is a patient with extraskeletal myxoid chondrosarcoma. PMID: 15188455
    19. TFG is a novel protein able to modulate SHP-1 activity. PMID: 15557341
    20. TFG enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity; it is suggested that TFG is a novel member of the NF-kappaB pathway PMID: 16547966

    顯示更多

    收起更多

  • 相關疾病:
    Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO); Spastic paraplegia 57, autosomal recessive (SPG57)
  • 亞細胞定位:
    Endoplasmic reticulum.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 11758

    OMIM: 602498

    KEGG: hsa:10342

    STRING: 9606.ENSP00000240851

    UniGene: Hs.518123



主站蜘蛛池模板: 久久天天躁狠狠躁夜夜96流白浆| 九九九国产精品成人免费视频| 国产日产欧产精品精品ai| 无码精品人妻一区二区三区98 | 国产乱妇无码大片在线观看| 免费人妻av无码专区| 亚洲无线观看国产精品| 娜娜麻豆国产电影| mm1313亚洲国产精品无码试看| 九九九免费观看视频| 国内偷自第一区二区三区| 日韩免费无码视频一区二区三区| 欧美放荡的少妇| 欧美午夜特黄aaaaaa片| 国产揄拍国产精品| 国内精品久久久久久影院8f| 一二三四区无产乱码1000集| 国产在线aaa片一区二区99| 国产末成年av在线播放| 日本亚洲欧美综合在线| 荫道bbwbbb高潮潮喷| 欧美性猛交xxxx富婆| 欲香欲色天天综合久久| 亚洲色大成网站www久久九九| 国产熟睡乱子伦视频| 成人爽a毛片免费网站| 亚洲精品无码少妇30p| 国产午夜亚洲精品午夜鲁丝片| 日本老熟妇乱| 亚洲久热中文字幕在线| av无码av在线a∨天堂毛片| 欧美老妇与禽交| 亚洲色18禁成人网站www| 久久久噜噜噜久久熟女色| 欧美人与性动交g欧美精器| 久久久久se色偷偷亚洲精品av| 亚洲乱码卡一卡二卡新区中国| 超清无码波多野吉衣中文| 极品少妇xxxx| 国产在热线精品视频99公交| 在线亚洲精品国产成人av剧情|