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  4. TFAP2E Antibody, FITC conjugated

TFAP2E Antibody, FITC conjugated

  • 中文名稱：
    TFAP2E兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA761516LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TFAP2E Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TFAP2E
  • 別名：
    TFAP2ETranscription factor AP-2-epsilon antibody; AP2-epsilon antibody; Activating enhancer-binding protein 2-epsilon antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription factor AP-2-epsilon protein (66-175AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
  • 基因功能參考文獻：
    1. Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma. PMID: 28260105
    2. Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer. PMID: 25810491
    3. AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer PMID: 24996990
    4. AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development. PMID: 23331625
    5. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. PMID: 22216841
    6. These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit. PMID: 20862309

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    AP-2 family
  • 組織特異性：
    Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
  • 數據庫鏈接：

    HGNC: 30774

    OMIM: 614428

    KEGG: hsa:339488

    STRING: 9606.ENSP00000362332

    UniGene: Hs.567844



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