在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TFAP2A Antibody

  • 中文名稱:
    TFAP2A兔多克隆抗體
  • 貨號:
    CSB-PA023414GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TFAP2A
  • 別名:
    Activating enhancer binding protein 2 alpha antibody; Activating enhancer-binding protein 2-alpha antibody; Activator protein 2 antibody; AP 2 transcription factor antibody; AP 2alpha antibody; AP-2 antibody; AP-2 transcription factor antibody; AP2 antibody; AP2 Transcription Factor antibody; AP2-alpha antibody; AP2A_HUMAN antibody; AP2TF antibody; BOFS antibody; FLJ51761 antibody; TFAP 2 antibody; TFAP 2A antibody; TFAP2 antibody; TFAP2A antibody; Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody; Transcription factor AP-2-alpha antibody; Transcription factor AP2 alpha antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TFAP2A,AP-2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
  • 基因功能參考文獻:
    1. The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development. PMID: 27933721
    2. Results show that gout-associated increased NRBP1 expression is regulated through methylation-dependent TFAP2A binding to the B1 region, which might be involved in the pathogenesis of gout. PMID: 28932319
    3. our results indicate that AP-2alpha can reverse the Multidrug resistance (MDR) of gastric cancer cells, which may be realized by inhibiting the Notch signaling pathway. PMID: 28439677
    4. High-confidence AP2alpha-binding peaks were detected in the regulatory regions of many target genes involved in the development of facial tissues including MSX1, IRF6, TBX22, and MAFB. In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2alpha consensus sequence. PMID: 24641171
    5. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients PMID: 27663566
    6. We identified miR-1254 as a negative regulator inhibiting HO-1 translation by directly targeting HO-1 3'UTR via its seed region, and suppressing HO-1 transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1. PMID: 28749936
    7. dimerization-defective mutant of Nef failed to interact with either CD4 or AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recruitment as well as CD4 down-regulation PMID: 28031466
    8. Data show that TFAP2A binds many of the same regulatory elements as MITF in melanocytes. PMID: 28249010
    9. the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF PMID: 27866707
    10. AP-2a is an important transcription factor of DEK expression, which is correlated with the methylation level of the DEK core promoter in hepatocellular carcinoma . PMID: 27499261
    11. AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration PMID: 26780928
    12. role in the expression of Latent membrane protein 1 PMID: 26819314
    13. Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha. PMID: 26073327
    14. Results indicate that AP-2alpha activates COX-2 expression to promote NPC growth. PMID: 25669978
    15. The AP-2alpha transcription factor may play an important role in suppressing glioma progression. PMID: 25674231
    16. TFAP2A might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID: 25953442
    17. INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. PMID: 25358080
    18. Human melanomas display higher than normal CpG DNA methylation at the TFAP2A promoter.Aberrant CpG DNA methylation as an epigenetic mark associated with TFAP2A silencing in human melanoma. PMID: 25625848
    19. ETS1 induction of syncytiotrophoblast marker genes likely results in part from transactivation by activator protein-2alpha. PMID: 25651508
    20. Direct sequencing of the coding region of the TFAP2A gene revealed missense mutations in four branchio-oculo-facial syndrome patients; one patient was observed to have a previously described mutation (p.Arg251Gly), while three patients from two families were found to have novel mutations: p.Arg213Ser and p.Val210Asp. PMID: 25590586
    21. AP-2alpha continues to be required after lens vesicle separation to maintain a normal lens epithelial cell phenotype and overall lens integrity and to ensure correct fiber cell differentiation. PMID: 24753151
    22. Cigarette smoke condensate decreased AP-2alpha expression by suppressing its transcription in human lung cancer cell lines, particularly in p53-deficient NCI-H1299 cells. PMID: 25050743
    23. AP2-mediated receptor internalization can be dissociated from AP2-mediated chemotaxis PMID: 24450359
    24. During pregnancy, regulation of hCG beta subunit genes expression correlates with both methylation of their promoters and TFAP2A expression level. PMID: 25063728
    25. TFAP2A regulates nasopharyngeal carcinoma growth and survival through the modulation of the HIF-1alpha-mediated VEGF/PEDF signaling pathway. PMID: 24335623
    26. These data define a mechanism through which AP-2alpha acetylation and increased promoter access induce the expression of the TLR2 gene. PMID: 23680675
    27. Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
    28. The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas. PMID: 23660954
    29. Result suggests that the individual TFAP2A Branchio-Oculo-Facial Syndrome mutations can generate null alleles. These mutations combined with a role for AP-2alpha in epigenetic events, may influence the resultant pathology and the phenotypic variability. PMID: 23578821
    30. TFAP2C repressed CD44 expression in basal-derived breast cancer. PMID: 23764310
    31. Molecular modeling of the HIV-1 Nef C-terminal flexible loop in complex with AP2 suggests that M168L170 occupies a pocket in the AP2 sigma2 subunit. PMID: 23151229
    32. ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
    33. results indicate that Kctd15 acts in the embryo at least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the function of this critical factor in the neural crest induction hierarchy. PMID: 23382213
    34. Evidence of association was obtained with both single marker and haplotype analyses, thus providing a support for TFAP2A in non-syndromic cleft lip with or without cleft palate aetiology PMID: 21781438
    35. The different pattern of activator protein-2alpha expression in mild and severe preeclampsia clearly suggests that these conditions may have 2 independent pathogenic mechanisms. PMID: 22575257
    36. A mutation in the TFAP2A gene associated with Branchio-Oculo-Facial syndrome (heterozygous H384Y in exon 7) was found in both the proband and her mother. PMID: 22191992
    37. a robust transcriptional CTNNAL1 up-regulation occurs during acute ozone-induced stress and is mediated at least in part by ozone-induced recruitments of LEF-1 and AP-2alpha to the human CTNNAL1 promoter. PMID: 22359570
    38. fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted PMID: 22484487
    39. findings suggest that TFAP2A isoforms may be differentially regulated during breast tumourigenesis and this, coupled with differences in their transcriptional activity, may impact on tumour responses to tamoxifen therapy PMID: 21375726
    40. AP2 regulates the inhibin alpha subunit gene expression during trophoblast differentiation and may be a key regulator of syncytialization PMID: 21659426
    41. Data suggest that AP-2alpha plays an important role in tumor progression and that reduced AP-2alpha expression independently predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 21966377
    42. AP-2alpha regulation of CHRNA7 mRNA expression in multiple tissues during development PMID: 21979958
    43. Bcl-2 gene transcription is regulated by Ap2alpha-Rb complex binding to the Bcl-2 promoter. PMID: 21850486
    44. findings provide a better understanding of the epigenetic mechanisms that are involved in the loss of AP-2alpha protein in prostate cancer cells which lead to decreased cellular zinc uptake-a sine qua non of prostate cancer development PMID: 21940908
    45. Patients with Branchio-Oculo-Facial Syndrome (BOFS) and predominant ocular phenotypes can be diagnosed by upper lip examination. TFAP2A analysis provides diagnostic confirmation and improves genetic counselling. PMID: 21728810
    46. Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor. PMID: 20731749
    47. A protein-binding microarrays-based study of human healthy and breast tumor tissue extracts allowed the identification of previously unknown AP2alpha target genes. PMID: 21876733
    48. These data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2alpha. PMID: 21777522
    49. Multiple isoforms of AP-2alpha are highly expressed in pancreatic cancer cell lines including a new isoform, AP-2alpha variant 6, which seems to be pancreatic cancer specific and is deprived of transcriptional activity. PMID: 21654541
    50. this study provides further evidence regarding the role of IRF6 variations in non-syndromic cleft lip with or without cleft palate (NSCLP) development and finds no significant association between TFAP2A and NSCLP in this northern Chinese population. PMID: 21683068

    顯示更多

    收起更多

  • 相關疾病:
    Branchiooculofacial syndrome (BOFS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    AP-2 family
  • 數據庫鏈接:

    HGNC: 11742

    OMIM: 107580

    KEGG: hsa:7020

    STRING: 9606.ENSP00000368924

    UniGene: Hs.519880



主站蜘蛛池模板: 青青视频免费观看免费| 色综合色狠狠天天综合网| 国产日产亚洲系列最新美使用方法 | 18禁又污又黄又爽的网站不卡| 国产人妖视频一区二区| 天堂中文在线资源| 国产无限次数成版人视频在线| 久久www色情成人免费观看| 欧美性猛交aaaa片黑人| 香蕉久久久久久久av网站| 亚洲暴爽av人人爽日日碰| 无码喷水一区二区浪潮av| 中文字幕人乱码中文字幕| 青春草在线视频免费观看| 国产主播一区二区三区在线观看| 日韩精品 中文字幕 视频在线 | 熟妇高潮精品一区二区三区| 亚洲婷婷五月综合狠狠爱| 一本一道波多野结衣一区| 天天躁夜夜躁狠狠综合| 中文字幕 人妻熟女| 国精产品一区一区三区有限在线| 精品一卡二卡三卡四卡网站| 亚洲а∨天堂男人色无码| 94久久国产乱子伦精品免费| 丰满爆乳在线播放| 无码人妻一区、二区、三区免费视频 | 无码被窝影院午夜看片爽爽jk| 午夜精品乱人伦小说区| 131美女爱做视频| 国产精品久久无码不卡黑寡妇 | 亚洲欧美精品午睡沙发| 日本亲与子乱人妻hd| 日日摸夜夜摸狠狠摸婷婷| 国产又黄又大又粗视频| 99国产精品自在自在久久| 人妻出轨av中文字幕| 青青草原精品资源站久久| 特级毛片爽www免费版| 99久久精品国产成人综合| 日韩不卡1卡2卡三卡2021精品推荐 |