在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TES Antibody, FITC conjugated

  • 中文名稱:
    TES兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA890679LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TES Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TES
  • 別名:
    DKFZP586B2022 antibody; MGC1146 antibody; TES antibody; TES_HUMAN antibody; TESS 2 antibody; TESS antibody; TESS2 antibody; Testin antibody; Testis derived transcript (3 LIM domains) antibody; Testis derived transcript antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Testin protein (130-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
  • 基因功能參考文獻:
    1. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes PMID: 28378594
    2. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways. PMID: 27323777
    3. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains PMID: 28542564
    4. Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor. PMID: 28000866
    5. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. PMID: 26611125
    6. we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest. PMID: 26985820
    7. Loss of TES gene expression is associated with nasopharyngeal carcinoma. PMID: 25824796
    8. findings suggest that the TES gene is a novel tumor suppressor gene PMID: 25498217
    9. TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis. PMID: 25720371
    10. Downregulation of TES was associated with breast cancer. PMID: 25119600
    11. TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers. PMID: 24929083
    12. A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression. PMID: 23715752
    13. TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment. PMID: 22957844
    14. Low TES gene expression is associated with coronary artery disease. PMID: 22156939
    15. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion PMID: 22201996
    16. These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton. PMID: 21843504
    17. data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis PMID: 20573277
    18. results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation PMID: 20626849
    19. The expression level of TES is significantly down-regulated in primary gastric cancer. PMID: 18799041
    20. TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers. PMID: 20180808
    21. TES is best candidate tumor suppressor gene at 7q31 in prostate tumors PMID: 15252854
    22. Loss of TES from focal adhesions results in loss of actin stress fibres. PMID: 15662727
    23. Oservations identify Tes as an atypical binding partner of EVH1 domain of Mena and a regulator specific to a single Ena/VASP family member. PMID: 18158903
    24. Results suggest that testin has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization. PMID: 18696217
    25. Inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. PMID: 19289703

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
  • 蛋白家族:
    Prickle / espinas / testin family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 14620

    OMIM: 606085

    KEGG: hsa:26136

    STRING: 9606.ENSP00000350937

    UniGene: Hs.592286



主站蜘蛛池模板: 少妇性l交大片| 亚洲精品nv久久久久久久久久| 最新精品香蕉在线| 中国熟妇牲交视频| 成年性午夜无码免费视频| 日本乱妇乱子视频| 精品亚洲麻豆1区2区3区| 丰满岳乱妇一区二区三区| 亚洲欧洲国产码专区在线观看| 亚洲伊人久久精品酒店| 免费观看黄网站在线播放| 久久综合久久鬼色| 国产伦人人人人人人性| 亚洲精品无码鲁网午夜| 日本三级吃奶头添泬无码苍井空| 久久亚洲精品成人av无码网站| 日本一道本高清一区二区| 小13箩利洗澡无码视频网站| 97色偷偷色噜噜狠狠爱网站| 东京热人妻无码一区二区av | 又爽又黄又无遮挡网站| 麻豆av久久av盛宴av| 中出人妻中文字幕无码| 国产av精品毛片一区二区三区| 97se亚洲精品一区二区| 国产精品免费福利久久| 亚洲永久精品ww47| 精品一卡二卡三卡四卡网站| 亚洲一卡2卡3卡4卡精品| 色欲色香天天天综合无码www| 亚洲伊人久久大香线蕉综合图片 | 2022国产日产欧产精品| 中国内地毛片免费高清| 精品视频一区二区三三区四区| 青椒国产97在线熟女| 亚洲乱码av中文一区二区| 熟女无套内射线观56| 久久99国产综合精品女同| 国产真人做爰视频免费| 国产午夜伦鲁鲁| 狠狠色噜噜狠狠狠7777米奇|