在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TERF1 Antibody, FITC conjugated

  • 中文名稱(chēng):
    TERF1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA023386EC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) TERF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    hTRF1 AS antibody; NIMA interacting protein 2 antibody; NIMA-interacting protein 2 antibody; PIN 2 antibody; PIN2 antibody; t TRF1 antibody; Telomeric protein Pin2 antibody; Telomeric protein Pin2/TRF1 antibody; Telomeric repeat binding factor (NIMA interacting) 1 antibody; Telomeric repeat binding factor 1 antibody; Telomeric repeat binding protein 1 antibody; Telomeric repeat-binding factor 1 antibody; TERF 1 antibody; Terf1 antibody; TERF1_HUMAN antibody; TRBF 1 antibody; TRBF1 antibody; TRF 1 antibody; TRF antibody; TTAGGG repeat binding factor 1 antibody; TTAGGG repeat-binding factor 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Telomeric repeat-binding factor 1 protein (260-439AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
  • 基因功能參考文獻(xiàn):
    1. Findings suggest that rescuing naturally decreased TRF1 levels during mouse aging using AAV9-TRF1 gene therapy results in an improved health span. PMID: 28944611
    2. Results provide evidence that TRF1 phosphorylation on T271 plays an important role in modulating its activity in both telomerease-expressing and alternative lengthening of telomeres cells. PMID: 27841304
    3. Both TRF1 and TRF2 were overexpressed in prostate cancer. There was no specificity of TRF2 in prostate cancer, while TRF1 may be associated with prostate cancer progression. PMID: 28808664
    4. study suggests that, gallstone does not affect telomere length and even after having increased telomere length, decreased expression of some shelterin genes in inflamed tissue might cause telomeres to cap improperly, possibly leading to telomere dysfunction and further, gallbladder carcinogenesis PMID: 28643740
    5. Data show that TRF1 expression is increased in both human and mouse glioblastoma multiforme (GBM). PMID: 29136505
    6. our results suggest that RhoGDIalpha regulate TRF1 and telomere length and may be novel prognostic biomarkers in colorectal cancer PMID: 28417530
    7. TRF1 phosphorylation by Nek7 favors the binding of shelterin protein TIN2 and disfavors E3 ligase Fbx4 interaction, thus preventing TRF1 ubiquitination and proteasome degradation to maintain telomere integrity. PMID: 28216227
    8. Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1. PMID: 27185864
    9. TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging PMID: 27298259
    10. data suggest that NUB1 participates in telomere maintenance by regulating the levels of TRF1 at telomeres through both NEDD8-dependent and NEDD8-independent pathways. PMID: 27214791
    11. Data indicate that overexpression of telomeric repeat binding factor 1 (TRF1) in aging endothelial cells (EC) reduced telomere-associated DNA damage foci. PMID: 26658719
    12. we provide mechanistic insight into the role of TRF1 in liver regeneration and provide a mouse model recapitulating the clinical features of LLCC. PMID: 25819337
    13. TRF1 links TopoIIalpha and SAC proteins in a pathway that ensures correct telomere replication and mitotic segregation, unveiling how TRF1 protects from telomere fragility and mitotic defects. PMID: 24626180
    14. ZSCAN4 indirectly interacts with TRF1 in cancer cells. We show that ZSCAN4 plays an important role independent of telomere maintenance pathways (telomerase positive and alternative pathway) or cell lineage. PMID: 26403970
    15. analysis of human telomere repeat binding factor 1 (hTRF1) in complex with Escherichia coli Hsp70 (DnaK) PMID: 26240333
    16. Results showed significant interaction between variants at TERF1 and AFAP1L2 loci. Given the key role of TERF1 in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development. PMID: 25892537
    17. Modulating miR-155 expression in cells altered TRF1 levels and TRF1 abundance at telomeres. Compromising TRF1 expression by elevating miR-155 increased telomere fragility and altered the structure of metaphase chromosomes. PMID: 24876105
    18. TAP68 functions in mediating TRF1-tankyrase 1 localization to the centrosome and in mitotic regulation PMID: 24692559
    19. this study demonstrates an essential role of TRF1 in the centromeric localization of Aurora-B kinase, which is required for correction of the merotelic attachment of microtubules to a single kinetochore and for proper chromosome segregation. PMID: 24752893
    20. TRF1 knockdown suppressed Nek2- induced lagging chromosomes, suggesting that TRF1 may affect kinetochore capture by mitotic spindles. PMID: 24091727
    21. these findings suggested that PinX1 may maintain telomere integrity by regulating TRF1 stability and that hTERT may act as both a positive and a negative regulator of TRF1 homeostasis in a PinX1-dependent manner. PMID: 24415760
    22. U2AF65 represents a new route for modulating TRF1 function at telomeres. PMID: 24389012
    23. Data show that RTEL1 interacts with the shelterin protein TRF1, indicating a potential recruitment mechanism of RTEL1 to telomeres. PMID: 23959892
    24. TRF1 is an important factor in the colorectal tumor progression and maybe a diagnostic factor PMID: 23268632
    25. This improved model also reveals extensive indirect readout, which suggests that telomere recognition by TRF1 will be affected by changes to DNA helical parameters such as bending. PMID: 23702294
    26. Results indicate that beta-TrCP1 is involved in the negative regulation of TRF1. PMID: 23583392
    27. Low TRF1 expression is associated with chronic lymphocytic leukemia. PMID: 22878603
    28. TRF1 binds to and stabilizes common fragile site on Chromosome 2q14. PMID: 22790221
    29. The TRF1 stimulates the binding and enzymatic activities of the LP-BER proteins APE1, FEN1 and LigI both individually and when they act together in reconstituted LP-BER using a telomeric substrate. PMID: 22336916
    30. The nucleostemin(NS)could promote the recruitment of PML-IV to SUMOylated TRF1 in TA(+) and ALT cells. PMID: 22641345
    31. Age-dependent telomere shortening occurs in Duchenne muscular dystrophy muscles and is associated with overexpression of mRNA and protein levels of TRF1 and poly (ADP-ribose) polymerase (PARP)1. PMID: 20137830
    32. one function of PinX1 is to stabilize TRF1 during mitosis, perhaps to promote transition into M phase of the cell cycle. PMID: 22331467
    33. It is found that water molecules around the DNA are more structured with significantly higher density and ordering than that around the protein in the complex. PMID: 22225189
    34. NS inhibits TRF1 dimerization and shortens TRF1 association with the telomere. PMID: 22045740
    35. A subset of TRF1 and TRF2 binding sites correspond to nontelomeric satellite DNA repeats. PMID: 21423270
    36. Mouse gene deletion experiments revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.[Shelterin] PMID: 21209389
    37. the telomerase inhibitor PinX1 is recruited to telomeres by TRF1 and provides a critical link between TRF1 and telomerase inhibition to prevent telomere elongation and help maintain telomere homeostasis. PMID: 21119197
    38. Monoclonal gammopathy of undetermined significance patients showed increased TRF1 levels and lower expression of TRF2 and TANK1 compared with multiple myeloma patients. PMID: 20644899
    39. the protein network surrounding telomere repeat binding factors, TRF1, TRF2, and POT1 using dual-tag affinity purification PMID: 20811636
    40. The expression of TRF1 may work to reduce the telomere length in precancerous lesions and offer new insight into the mechanism of carcinogenesis in gastric cancer. PMID: 20127252
    41. Atomic Force Microscopy imaging shows that hTRF1 induces compaction of telomeric DNA only in the presence of a nucleosome, suggesting that this compaction occurs through hTRF1-nucleosome interactions. PMID: 20056655
    42. results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control PMID: 20159592
    43. Kinetic analysis of DNA-dependent intrinsic tryptophan fluorescence quenching of hTRF1 revealed a two step binding process that is impacted by telomere repeat length, position, and structure PMID: 19887064
    44. nuclear localization signal and nuclear export signal sequences in NSCLCs patients did not have mutations. PMID: 19746267
    45. inhibition of Pin2/TRF1 in A-T cells is able to bypass the requirement for ATM in specifically restoring telomere shortening, the G(2)/M checkpoint defect, and radiosensitivity PMID: 11744712
    46. Isoform PIN2 interacts with the human SALL1 gene product. PMID: 11751684
    47. tumour growth does not seem to depend on cell proliferation but on TRF1 immunoexpression PMID: 11813863
    48. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). PMID: 11854288
    49. Results showed that targeting of TRF1 and TRF2 to specific telomeres could be induced, and that targeting leads to telomere shortening. This indicates that these proteins act in cis to repress telomere elongation. PMID: 11971978
    50. Gastric carcinomas with high TRF1 expression may require a large quantity of hRap1/ PMID: 12007281

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
  • 組織特異性:
    Highly expressed and ubiquitous. Isoform Pin2 predominates.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11728

    OMIM: 600951

    KEGG: hsa:7013

    STRING: 9606.ENSP00000276603

    UniGene: Hs.442707



主站蜘蛛池模板: 国产精品亚洲一区二区| 亚洲中文字幕无码中文字在线 | 中文字字幕在线中文乱码| 无码人妻aⅴ一区二区三区玉蒲团| 自拍偷在线精品自拍偷99| 久激情内射婷内射蜜桃人妖| 欧美人与动zozo在线播放| 午夜国产亚洲精品一区| 一区二区三区无码免费看| 男女下面进入的视频免费午夜| 午夜片无码区私人影院| 国产精品乱码一区二区三| 狠狠色丁香婷婷综合尤物| 国产精品星空无限传媒| 亚洲综合欧美在线一区在线播放| 777米奇色狠狠888俺也去乱| 色爽黄1000部免费软件下载| 色爱区综合五月激情| 中文国产乱码在线人妻一区二区 | 久久久无码人妻精品无码| 四虎影视久久久免费观看| 日韩精品无码专区免费视频| 任我橹这里只有精品 在线视频| 思思99热久久精品在线6| 国产精品国产三级国产av主播| 国产舌乚八伦偷品w中| 在线看片无码永久av| 97国语精品自产拍在线观看| 2021无码天堂在线| 特黄熟妇丰满人妻无码| 性欧美大胆免费播放| 中文字幕无码人妻少妇免费| 97人妻无码专区| 香蕉在线 亚洲 欧美 专区 | 唐人社导航福利精品| 亚洲香蕉视频天天爽| 女人夜夜春高潮爽a∨片传媒| 亚洲精品av无码喷奶水网站| 成熟丰满熟妇高潮xxxxx| 另类老妇奶性生bbwbbw| 国产精品成人一区二区不卡|