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  4. TELO2 Antibody

TELO2 Antibody

  • 中文名稱：
    TELO2兔多克隆抗體
  • 貨號：
    CSB-PA023382GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CLK2 antibody; hCLK2 antibody; KIAA0683 antibody; Protein clk-2 homolog antibody; TEL2 antibody; TEL2 telomere maintenance 2 homolog antibody; TEL2, telomere maintenance 2, homolog antibody; telo2 antibody; TELO2_HUMAN antibody; Telomere length regulation protein TEL2 homolog antibody; Telomere maintenance 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TELO2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
  • 基因功能參考文獻：
    1. Taken together, human high-grade gliomas increase TELO2 mRNA expression, and overexpression of TELO2 mRNA expression correlates with shorter survival outcome, supporting that TELO2 is an oncotarget in human gliomas. PMID: 27329594
    2. TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder. PMID: 27132593
    3. The SAM domain of human TEL2 can inhibit the transcriptional activities of ETS1/2 and TEL1. PMID: 22615925
    4. The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo. PMID: 20864032
    5. TTI1 and TTI2 exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM). PMID: 20810650

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  • 相關疾病：
    You-Hoover-Fong syndrome (YHFS)
  • 亞細胞定位：
    Cytoplasm. Membrane. Nucleus. Chromosome, telomere.
  • 蛋白家族：
    TEL2 family
  • 數據庫鏈接：

    HGNC: 29099

    OMIM: 611140

    KEGG: hsa:9894

    STRING: 9606.ENSP00000262319

    UniGene: Hs.271044



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