在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TELO2 Antibody

TELO2 Antibody

  • 中文名稱：
    TELO2兔多克隆抗體
  • 貨號：
    CSB-PA023382GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CLK2 antibody; hCLK2 antibody; KIAA0683 antibody; Protein clk-2 homolog antibody; TEL2 antibody; TEL2 telomere maintenance 2 homolog antibody; TEL2, telomere maintenance 2, homolog antibody; telo2 antibody; TELO2_HUMAN antibody; Telomere length regulation protein TEL2 homolog antibody; Telomere maintenance 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TELO2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
  • 基因功能參考文獻：
    1. Taken together, human high-grade gliomas increase TELO2 mRNA expression, and overexpression of TELO2 mRNA expression correlates with shorter survival outcome, supporting that TELO2 is an oncotarget in human gliomas. PMID: 27329594
    2. TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder. PMID: 27132593
    3. The SAM domain of human TEL2 can inhibit the transcriptional activities of ETS1/2 and TEL1. PMID: 22615925
    4. The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo. PMID: 20864032
    5. TTI1 and TTI2 exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM). PMID: 20810650

    顯示更多

    收起更多

  • 相關疾病：
    You-Hoover-Fong syndrome (YHFS)
  • 亞細胞定位：
    Cytoplasm. Membrane. Nucleus. Chromosome, telomere.
  • 蛋白家族：
    TEL2 family
  • 數據庫鏈接：

    HGNC: 29099

    OMIM: 611140

    KEGG: hsa:9894

    STRING: 9606.ENSP00000262319

    UniGene: Hs.271044



主站蜘蛛池模板： 亚洲精品天堂成人片av在线播放 | 日本真人边吃奶边做爽免费视频 | 男女啪啪永久免费观看网站| 久久午夜夜伦鲁鲁片无码免费| 亚洲欧洲日产韩国在线看片| 在线看午夜福利片国产| 扒开女人内裤猛进猛出免费视频| 又大又黄又粗又爽的免费视频| 亚洲欧洲无码av电影在线观看| 中文字幕大看蕉在线观看| 自拍偷亚洲产在线观看| av无码人妻中文字幕| 久久久噜噜噜www成人网| 特级做a爰片毛片免费看无码| 波多野结衣aⅴ在线| 中国内射xxxx6981少妇| 亚洲乱码日产精品bd在观看| 亚洲免费观看在线视频| 国精品午夜福利视频不卡| 国产激情综合在线看| 国产卡一卡二卡三精品| 欧美人与动牲交aⅴ| 国产欧美综合一区二区三区| 小说区亚洲综合第1页| 亚洲国产码专区| 成年美女黄网站色大片免费看| 久久久久久久久免费看无码| 137日本免费肉体摄影| 亚洲综合中文字幕无线码| 国产精品久久午夜夜伦鲁鲁| 免费一本色道久久一区| 国产成人年无码av片在线观看| 少妇仑乱a毛片| 丰满人妻熟妇乱又伦精品视 | 亚洲色成人www永久网站| 成人一区二区免费中文字幕视频| av天堂午夜精品蜜臀av| 5566先锋影音夜色资源站在线观看| 午夜在线a亚洲v天堂网2018| 蜜桃麻豆www久久国产sex| 人妻一本久道久久综合久久鬼色|