在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TEAD4 Antibody

  • 中文名稱:
    TEAD4兔多克隆抗體
  • 貨號:
    CSB-PA618010LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate
      All lanes: TEAD4 antibody at 2.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 49, 35, 45 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618010LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TEAD4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    EFTR 2 antibody; EFTR2 antibody; hRTEF 1B antibody; hRTEF1B antibody; MGC9014 antibody; OTTHUMP00000238119 antibody; OTTHUMP00000238122 antibody; OTTHUMP00000238124 antibody; Related to TEF 1 antibody; Related to TEF1 antibody; Related transcription enhancer factor 1B antibody; RTEF1 antibody; TCF13L1 antibody; TEA domain family member 4 antibody; TEAD 4 antibody; TEAD-4 antibody; TEAD4 antibody; TEAD4_HUMAN antibody; TEF 3 antibody; TEF3 antibody; TEFR 1 antibody; TEFR1 antibody; Transcription factor 13 (SV40 transcriptional enhancer factor) like 1 antibody; Transcription factor 13 like 1 antibody; Transcription factor 13-like 1 antibody; Transcription factor RTEF 1 antibody; Transcription factor RTEF-1 antibody; Transcription factor RTEF1 antibody; Transcriptional enhancer factor 1 related antibody; Transcriptional enhancer factor 3 antibody; Transcriptional enhancer factor TEF 3 antibody; Transcriptional enhancer factor TEF-3 antibody; Transcriptional enhancer factor TEF3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcriptional enhancer factor TEF-3 protein (74-434AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,TEAD4 Antibody (CSB-PA618010LA01HU),的標記方式是Non-conjugated。對于TEAD4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA618010LB01HU TEAD4 Antibody, HRP conjugated ELISA
    FITC CSB-PA618010LC01HU TEAD4 Antibody, FITC conjugated
    Biotin CSB-PA618010LD01HU TEAD4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

產品評價

靶點詳情

  • 功能:
    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
  • 基因功能參考文獻:
    1. TEAD4, the transcription factor that mediates Hippo-YAP signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4. PMID: 27291620
    2. Combining single site-directed mutagenesis and double mutant analyses, the authors conduct a detailed analysis on the role of several residues located at the YAP:TEAD interface. The results provide quantitative understanding of the interactions taking place at the YAP:TEAD interface and give insights into the formation of the YAP:TEAD complex and more particularly on the interaction between TEAD and the ohm-loop found ... PMID: 28430104
    3. Studied the effect of TEAD4 acylation on its interaction with YAP and TAZ; found YAP and TAZ bind in a similar manner to both acylated and non-acylated TEAD4. Also found TEAD4 acylation significantly enhances its stability. PMID: 28960584
    4. High TEF3 expression is associated with cell cycle progression and angiogenesis in colon cancer. PMID: 26885617
    5. Osmotic stress promotes TEAD4 cytoplasmic translocation via p38 MAPK in a Hippo-independent manner. Stress-induced TEAD inhibition predominates YAP-activating signals and selectively suppresses YAP-driven cancer cell growth. PMID: 28752853
    6. The transcription factor TEAD4 regulates a pro-metastasis transcription program in a YAP-independent manner in CRC, thus providing a novel mechanism of TEAD4 transcriptional regulation and its oncogenic role in CRC, independently of the Hippo pathway. PMID: 26387538
    7. our work provides a structural basis for understanding the regulatory mechanism of TEAD4-mediated gene transcription PMID: 28368398
    8. Our results suggest that TEAD4 plays a role in the pathophysiology of atypical teratoid/rhabdoid tumor, which represents a new insight into the biology of this aggressive tumor PMID: 27966820
    9. It was found that the TEAD4-YAP complex in the nuclei may be related closely to transcriptions of G1 arrest-related genes. PMID: 28315328
    10. Tead4 cooperates with AP1 transcription factors to coordinate target gene transcription. PMID: 26832411
    11. TEAD4 and KLF5, in collaboration, promoted triple negative breast cancer cell proliferation and tumor growth in part by inhibiting p27 gene transcription PMID: 25970772
    12. potential anti-oxidation gene and can prevent H2O2-induced endothelial cell oxidative damage by activating Klotho PMID: 26041389
    13. TEAD4 overexpression induced p16 in HAoSMCs homozygous for the nonrisk coronary disease allele, but not for the risk allele. PMID: 26487755
    14. the peptides TEF3-11-66 and TEF3-1197-434 functioned as two independent activation domains, suggesting that N-terminal domain of TEF3-1 also has transcriptional activation capacity PMID: 25687649
    15. Edg-1 is a potential target gene of RTEF-1 and is involved in RTEF-1-induced angiogenesis in endothelial cells. PMID: 24520353
    16. the multilevel perturbations of TEAD4 at epigenetic, transcriptional and posttranslational levels may contribute to GC development. PMID: 24325916
    17. These data suggest that TFF3 and survivin expressions play a vital role in gastric cancer development, and these two proteins are important markers for prognosis in gastric cancer. PMID: 22996285
    18. convergent optimization of the YAP/TAZ TEAD binding site suggests that the similarity in the affinities of binding of YAP to TEAD and of TAZ to TEAD is important for Hippo pathway functionality. PMID: 23780915
    19. High TEAD4 expression is associated with Age-Related Macular Degeneration. PMID: 22761647
    20. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
    21. Blocking connexin 43 function inhibited RTEF-1-induced endothelial cell connections and aggregation PMID: 22652601
    22. RTEF-1 plays an important role in FGFR1- stimulated vasodilatation. PMID: 22433836
    23. RTEF-1 as a regulator of HIF-1alpha transcription PMID: 21540178
    24. the RTEF-1-driven increase of VEGF-B plays an important role in communication between the endothelium and myocardium PMID: 21169295
    25. TEF3, mainly its nuclear localization, is required for VEGF-A(165)-induced endothelial proliferation, migration, tube formation, and in vivo Matrigel angiogenesis. PMID: 21169383
    26. Constitutive activation of alpha1-adrenergic signaling through the RTEF-1 transcription factor results in chronic elevation of PP1beta expression and connexin dephosphorylation. This mechanism may underlie some defects in cardiac conduction. PMID: 15520314
    27. Novel RTEF-1 transcripts are present within human ocular vascular endothelial cells and mouse neural retina during normal and retinopathy of prematurity development, and alternatively spliced products are produced under hyperoxic and hypoxic conditions PMID: 17652751
    28. The gain of function studies indicated that TEA domain family member 4 activate NR5A1 gene expression. PMID: 18579725
    29. TEF3 mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells PMID: 18840614
    30. The paper described several reasons to designate the putative translation initiation codon as the leucine (TTG) codon, which is 7 codons upstream from the isoleucine (ATT) codon. PMID: 8921372
    31. The paper described that the ORF of TEF-3 initiates with an ATT codon encoding isoleucine. PMID: 8702974

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
  • 數據庫鏈接:

    HGNC: 11717

    OMIM: 601714

    KEGG: hsa:7004

    STRING: 9606.ENSP00000352926

    UniGene: Hs.94865



主站蜘蛛池模板: 720lu国产刺激无码| 亚洲欧洲国产成人综合在线观看 | 99精品国产兔费观看久久99| 亚洲有无码av在线播放| 女人裸露免费视频无遮挡网站| 亚洲h成年动漫在线观看网站| 久久久久人妻一区视色| 成人精品天堂一区二区三区| 亚洲色偷拍另类无码专区| 自愉自愉产区二十四区| 人人妻人人澡人人爽国产| 日韩人妻潮喷中文在线视频| 亚洲熟妇av日韩熟妇av| 亚洲精品v日韩精品| 日韩人妻一区二区三区蜜桃视频| 人妻少妇精品视频一区二区三区| 狠狠做深爱婷婷久久综合一区 | 一二三四免费观看在线视频中文版| 女女同性av片在线观看免费 | 久久先锋男人av资源网站| 四虎亚洲精品无码| 在线亚洲中文精品第1页| 无码成a毛片免费| 国产成人精品日本亚洲77上位| 国产在线无码制服丝袜无码| 国产午夜精品一二区理论影院| 天堂а√在线地址8| 精品久久久久中文字幕一区| 国产成人vr精品a视频| 国产精品嫩草影院久久| 高清同性男毛片| 欧美老熟妇乱子| 青青草国产成人99久久| 国产午夜大地久久| 国产成人精品一区二区不卡| 国色天香社区视频| 国产精品原创巨作av| 国内久久婷婷五月综合色| 亚洲精品专区成人网站| 欧美一区二区三区红桃小说| 少妇久久久久久久久久|