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TEAD2 Antibody

  • 中文名稱:
    TEAD2兔多克隆抗體
  • 貨號:
    CSB-PA070034
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of mouse-brain cells using TEF-4 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Embryonic TEA domain containing factor antibody; Etdf antibody; ETEF 1 antibody; ETF antibody; TEA domain family member 2 antibody; TEAD 2 antibody; TEAD-2 antibody; TEAD2 antibody; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody; TEAD2_HUMAN antibody; TEF 4 antibody; TEF4 antibody; Transcriptional enhancer factor 4 antibody; Transcriptional enhancer factor TEF 4 antibody; Transcriptional enhancer factor TEF-4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human TEF-4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
  • 基因功能參考文獻:
    1. TAZ negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors. PMID: 25995450
    2. structural and functional analysis of the YAP-binding domain of human TEAD2 PMID: 20368466
  • 亞細胞定位:
    Nucleus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11715

    OMIM: 601729

    KEGG: hsa:8463

    STRING: 9606.ENSP00000310701

    UniGene: Hs.515534



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