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  4. TCF20 Antibody, Biotin conjugated

TCF20 Antibody, Biotin conjugated

  • 中文名稱：
    TCF20兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA887024LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TCF20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TCF20
  • 別名：
    TCF20 antibody; KIAA0292 antibody; SPBP antibody; Transcription factor 20 antibody; TCF-20 antibody; Nuclear factor SPBP antibody; Protein AR1 antibody; Stromelysin-1 PDGF-responsive element-binding protein antibody; SPRE-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription factor 20 protein (539-704AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
  • 基因功能參考文獻：
    1. Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum. PMID: 27436265
    2. mutations in TCF20 are associated with Autism spectrum disorders PMID: 25228304
    3. SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. PMID: 24416372
    4. evolutionary conservation of chromatin binding of SPBP and RAI1 PMID: 24205348
    5. Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. PMID: 21935435
    6. SPBP behaves as a repressor of activated ERalpha PMID: 15831449
    7. Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. PMID: 17913746

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
  • 數據庫鏈接：

    HGNC: 11631

    OMIM: 603107

    KEGG: hsa:6942

    STRING: 9606.ENSP00000352463

    UniGene: Hs.475018



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