在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TCEB1 Antibody

TCEB1 Antibody

  • 中文名稱：
    TCEB1兔多克隆抗體
  • 貨號：
    CSB-PA037081
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA037081(TCEB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Elo C antibody; EloC antibody; ELOC_HUMAN antibody; Elongin 15 kDa subunit antibody; Elongin C antibody; Elongin-C antibody; ElonginC antibody; RNA polymerase II transcription factor SIII subunit C antibody; SIII antibody; SIII p15 antibody; TCEB 1 antibody; tceb1 antibody; Transcription elongation factor B (SIII) polypeptide 1 antibody; Transcription elongation factor B polypeptide 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Full length fusion protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This includes the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.
  • 基因功能參考文獻：
    1. crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments. PMID: 26121586
    2. TCEB1-mutated renal cell carcinoma is a distinct entity with recurrent hotspot mutations, specific copy number alterations, pathway activation, and characteristic morphological features. PMID: 25676555
    3. The crystal structure of VHL bound to a Cul2 N-terminal domain, Elongin B, and Elongin C. PMID: 25661653
    4. Vif interaction with EloB-EloC may contribute to recruitment of CBF-beta to Vif, demonstrating that the EloB C-teminus may play a role in improving Vif function and that the over-expression of EloB results in Vif stabilization. PMID: 23988114
    5. AFF1 is a ubiquitous P-TEFb partner; full Tat transactivation requires the complete super elongation complexes PMID: 24367103
    6. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
    7. PRAME expression in leukaemic cell lines is upregulated by IFN gamma and LPS, suggesting a possible role in immune responses. PRAME associates with Elongin BC complexes by binding Elongin C. PMID: 23460923
    8. TCEB1 and SELC14L1 are good candidate markers for predicting prognosis and progression of prostate cancer. PMID: 23083832
    9. Functional interaction of Notch4(ICD) and Elongin C provides novel insight into regulation of Notch signaling in epithelial cell biology and disease. PMID: 22001063
    10. Recombinant full-length Vif interacted with the Elongin BC complex in vitro with a K(d) of 1.9 muM and resulted in observable changes in deuterium uptake in both Elongin C and B. PMID: 20728451
    11. These findings suggest that Elongin c may be one of the target genes for amplification of 8q21 PMID: 12004003
    12. findings report that HIV-1 Vif interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-cullin-F-box (SCF)-like complex PMID: 14564014
    13. specific Elongin C and Skp1 sequences determine Cullin selection PMID: 15280393
    14. show that ASB2, by interacting with the Elongin BC complex, can assemble with Cullin5.Rbx1 to form an E3 ubiquitin ligase complex that stimulates polyubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5 PMID: 15590664
    15. the E3 ubiquitin ligase activity of the Vif-BC-Cul5 complex is essential for Vif function against APOBEC3G PMID: 15781449
    16. Results describe the 1.9-A crystal structure of the ternary complex of SOCS2 with elongin C and elongin B. PMID: 16675548
    17. Elongin B/C recruitment regulates substrate binding by CIS PMID: 18508766
    18. TCEB1 promotes invasion of prostate cancer cells and is involved in development of hormone-refractory prostate cancer PMID: 18844214

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SKP1 family
  • 組織特異性：
    Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.
  • 數據庫鏈接：

    HGNC: 11617

    OMIM: 600788

    KEGG: hsa:6921

    STRING: 9606.ENSP00000284811

    UniGene: Hs.533437



主站蜘蛛池模板： 少妇放荡的呻吟干柴烈火动漫| 亚洲午夜av久久久精品影院色戒| 亚洲国产aⅴ综合网| 亚洲国产成人一区二区三区| 内射爽无广熟女亚洲| 人妻 色综合网站| 蜜桃无码一区二区三区| 国产亚洲成av人片在线观看 | 久久久久国产精品嫩草影院 | 狠狠色噜噜狠狠狠7777米奇| 伊人精品成人久久综合| 久久热最新网站获取| 伊人色合天天久久综合网| 国产精品午夜无码av天美传媒| 中国女人内谢69xxxxxa片| 久久精品人妻一区二区三区 | 国产成人无码av大片大片在线观看| 久久不见久久见www电影免费| 波多野结衣人妻| 久久99精品久久久久久秒播| 亚洲色在线v中文字幕| 精品国产一区二区三区国产区| 国产精品亚洲一区二区z| 人妻少妇精品中文字幕av蜜桃| 国产肥熟女视频一区二区三区| 伊人久久久av老熟妇色| ww欧日韩视频高清在线| 热99re久久精品这里都是精品免费 | 亚洲熟女精品中文字幕| 久久性色欲av免费精品观看| 国内少妇高潮嗷嗷叫在线播放 | 色偷偷www.8888在线观看 | 人妻无码系列一区二区三区| 人妻va精品va欧美va| 波多野结衣av手机在线观看| 无码高潮又爽又黄a片软件| 邻居少妇张开腿让我爽了一夜 | 麻豆一区二区99久久久久| 4hu四虎永久在线观看| 国产激情久久久久影院小草| 午夜性爽视频男人的天堂|