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Your Good Partner in Biology Research

TCEA3 Antibody, HRP conjugated

  • 中文名稱:
    TCEA3兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA023271LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TCEA3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TCEA3
  • 別名:
    Rhabdomyosarcoma antigen MU RMS 40.22 antibody; Tcea3 antibody; TCEA3_HUMAN antibody; TFIIS antibody; TFIIS.H antibody; Transcription elongation factor A (SII) 3 antibody; Transcription elongation factor A protein 3 antibody; Transcription elongation factor A3 antibody; Transcription elongation factor S-II protein 3 antibody; Transcription elongation factor TFIIS.h antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription elongation factor A protein 3 protein (79-169AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
  • 基因功能參考文獻:
    1. Findings reveal a novel mechanism by which p53 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging cell death in response to severe DNA damage. PMID: 27005522
    2. TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells PMID: 26498664
    3. Tcea3 binds to TGF-beta I receptor and activates TGF-beta signaling pathway. PMID: 23357533
    4. Study demonstrates a strong synergy between hPAF1C and elongation factor SII/TFIIS and an underlying mechanism involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II. PMID: 20178742
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    TFS-II family
  • 數據庫鏈接:

    HGNC: 11615

    OMIM: 604128

    KEGG: hsa:6920

    STRING: 9606.ENSP00000406293

    UniGene: Hs.446354



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