在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TBXAS1 Antibody

  • 中文名稱:
    TBXAS1兔多克隆抗體
  • 貨號:
    CSB-PA589726
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells, using THAS antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TBXAS1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TBXAS1
  • 別名:
    TBXAS1; CYP5; CYP5A1; TXAS; Thromboxane-A synthase; TXA synthase; TXS; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human THAS.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
  • 基因功能參考文獻:
    1. RS41708TT is not only independent risk factor for symptomatic carotid artery or intracranial arterial stenosis, but is also independent risk predictor for neurologic deterioration in ischemic stroke patients. PMID: 28108096
    2. Sequencing revealed two novel biallelic variants of unknown significance within the thromboxane A synthase gene, TBXAS1 (c.266T > C; c.989T > C), bioinformatically predicted to disrupt the protein. TBXAS1 mutations result in Ghosal hematodiaphyseal dysplasia (OMIM 231095), the autosomal recessive syndrome associated with abnormal bone structure and BMF. PMID: 28868793
    3. TXAS1 rs2267679TT and rs41708TT genotypes are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. PMID: 28704403
    4. the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples. PMID: 26974824
    5. Single nucleotide polymorphisms of TBXAS1 are associated with susceptibility to gout in ethnic Han males population. PMID: 26252103
    6. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1. PMID: 26117917
    7. The carriage of Thromboxane A synthase 1 gene polymorphism AA was shown to affect the risk of clopidogrel resistance. PMID: 26027242
    8. study suggests that the anti-tumor effect of glycyrrhizin in lung adenocarcinoma is, at least in part, TxAS-dependent. PMID: 24556579
    9. 12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi PMID: 24009185
    10. In this study we have showed, for the first time, a significant role of the minor allele rs6962291 of TBXAS1 in patients with NSAID acute cutaneous hypersensitivity. PMID: 23763970
    11. The increased Km and decreased Vmax values observed with L357V suggest that this variant may generate less TXA2 at the low levels of PGH2 expected in vivo, raising the possibility of attenuated signaling through the thromboxane pathway. PMID: 22735388
    12. Data show that that DNA methylation of the TBXAS1 promoter was decreased and thromboxane synthase expression was increased in omental arteries of preeclamptic women as compared with normal pregnant women. PMID: 22493072
    13. these results showed that visfatin promoted IL-8 production by upregulation of TXAS, leading to angiogenic activation in endothelial cells. PMID: 22293189
    14. Rs10487667 polymorphism in the CYP5A1 gene might be a risk factor of myocardial infarction in the Uigur population in Xinjiang. PMID: 21215134
    15. Data suggest that targeting thromboxane synthase alone, or in combination with conventional chemotherapy is a potential therapeutic strategy for NSCLC. PMID: 21388528
    16. The rare allele of rs6962291 may play a protective role against aspirin hypersensitivity via a lower catalytic activity of the TBXAS1 gene, attributed to the increase of a nonfunctioning isoform of TBXAS1. PMID: 21449675
    17. The TC genotype and T allele of thromboxane synthase are risk factors of myocardial infarction. PMID: 20931532
    18. Apoptosis induced in lung cancer cells by the thromboxane synthase inhibitor 1-benzylimidazole is associated with the over-production of ROS and the reduction of NF-kappaB. PMID: 20647010
    19. In humans, TXAS was expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages, and increased in atherosclerotic lesions of patients with recent symptoms of thrombotic events. PMID: 20383787
    20. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. PMID: 11782360
    21. Transcriptional control of the human thromboxane synthase gene in vivo and in vitro. PMID: 11956185
    22. structure and function of the gene and protein - review PMID: 12432933
    23. Cox-2 and TBXAS may play an important role in pituitary tumor development and progression PMID: 15067173
    24. Significantly higher expression of thromboxane synthase is associated with metastasis in non-small cell lung cancer PMID: 15870920
    25. Overexpression of thromboxane synthase is associated with invasive bladder cancer PMID: 16357168
    26. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). PMID: 18264100
    27. TBXAS1 genetic variation is associated with incident myocardial infarction. PMID: 19046748
    28. The results suggest specific TBXAS1 gene polymorphisms may be a useful marker for development of cerebral infarction, especially SAO type in Korean population. PMID: 19403042

    顯示更多

    收起更多

  • 相關疾病:
    Ghosal hematodiaphyseal dysplasia (GHDD)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cytochrome P450 family
  • 組織特異性:
    Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
  • 數據庫鏈接:

    HGNC: 11609

    OMIM: 231095

    KEGG: hsa:6916

    UniGene: Hs.520757



主站蜘蛛池模板: 久久久久久国产精品美女| 久久这里只有精品首页| 精品人伦一区二区三区潘金莲| 国产精品久久人妻无码网站一区| 国产xxxx做受性欧美88| 亚洲精品综合一区二区三| 韩日综合成人中文字幕| 成年美女黄网站色大片免费看| 处破痛哭a√18成年片免费| 18禁美女黄网站色大片免费网站 | 欧美国产日韩a在线观看| 久久久女人与动物群交毛片| 亚洲最大av网站在线观看 | 欧美性潮喷xxxxx免费视频看| 男人一边吃奶一边做爰免费视频| √天堂中文www官网在线| 华人在线亚洲欧美精品| 国产人妻精品一区二区三首| 成年女人免费碰碰视频| 无码精品人妻一区二区三区人妻斩| 亚洲精品日韩一区二区小说| 人人妻人人爽人人爽| 香港三级精品三级在线专区| 色综合天天综合网中文| 乌克兰美女浓毛bbw| 国产精品无套呻吟在线| 2021年精品国产福利在线| 国产尤物精品自在拍视频首页| 免费无码毛片一区二区app| 成人国产mv免费视频| 亚洲中文字慕日产2021| 啪啪无码人妻丰满熟妇| 国产一区二区三区| 99热久久这里只精品国产www| 亚洲成av人片一区二区三区| 亚洲日韩v无码中文字幕 | 国产jjizz女人多水| 特级做a爰片毛片免费看| 日本肉体xxxx裸交| 国产在线看片免费观看| 欧美 日本 国产 在线a∨观看|