在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TBC1D4 Antibody, HRP conjugated

  • 中文名稱:
    TBC1D4兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA023218LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TBC1D4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Acrg embryonic lethality (mouse) minimal region ortholog antibody; Acrg embryonic lethality minimal region ortholog antibody; Acrg embryonic lethality mouse minimal region ortholog antibody; Akt substrate of 160 kDa antibody; AS 160 antibody; AS160 antibody; BUB2 antibody; CDC16 antibody; KIAA0603 antibody; NIDDM5 antibody; TBC (Tre 2 BUB2 CDC16) domain containing protein antibody; TBC Tre 2 BUB2 CDC16 domain containing protein antibody; TBC1 D4 antibody; TBC1 domain family member 4 antibody; Tbc1d4 antibody; TBCD4_HUMAN antibody; Tre-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human TBC1 domain family member 4 protein (1-94AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
  • 基因功能參考文獻:
    1. C-terminal region (CTR) region is largely alpha-helical and mediates TBC1D4 RabGAP dimerization PMID: 28545963
    2. Disruption of TBC1D4 is common among North American Inuit, resulting in exclusively elevated postprandial glucose. This leads to underdiagnosis of type 2 diabetes, unless an OGTT is performed. PMID: 27561922
    3. AS160 regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle. PMID: 27152871
    4. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
    5. homozygous carriers of a nonsense p.Arg684Ter variant have markedly higher concentrations of plasma glucose and serum insulin 2 hours after an oral glucose load compared with individuals with other genotypes PMID: 25043022
    6. Findings suggest that a dampening of insulin-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin resistance evident in a sedentary aging population PMID: 23801578
    7. insulin resistance in muscles from healthy individuals is associated with suppression of site-specific phosphorylation of AS160 PMID: 22028408
    8. AS160 interacts with the large cytoplasmic NP domain of the alpha-subunit of the Na(+),K(+)-ATPase. AMP-stimulated protein kinase (AMPK) and AS160 participate in a common pathway to modulate the cell surface expression of the Na(+),K(+)-ATPase. PMID: 20943949
    9. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
    10. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane PMID: 21454690
    11. Impaired insulin-induced site-specific TBC1D4 phosphorylation may contribute to skeletal muscle insulin resistance in type 2 diabetes. PMID: 20938636
    12. results show AS160 phosphorylation level is frequently increased in breast cancer; results implicate a possible role of AS160 in breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target PMID: 20574165
    13. WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex PMID: 20937822
    14. S711 is a novel TBC1D4 phosphorylation site regulated by AMPK in skeletal muscle. PMID: 19923418
    15. KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells in atopic dermatitis PMID: 15304337
    16. In this study, we determined the expression of and in vivo insulin action on AS160 in skeletal muscle of normal and type 2 diabetic patients. PMID: 15919790
    17. results indicate that AS160 is a Rab GAP, and suggest novel Rabs that may participate in GLUT4 translocation PMID: 15971998
    18. AS160 is phosphorylated in a time-dependent manner during moderate-intensity exercise. PMID: 17077344
    19. Regulation of AS160 and interaction with 14-3-3 in skeletal muscle are influenced by resistance exercise and insulin but do not fully explain the effect of resistance exercise on whole-body insulin action. PMID: 17369524
    20. Effects of endurance exercise training on insulin signaling and AS160 in human skeletal muscle PMID: 17513702
    21. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058
    22. Impaired insulin signaling through Akt and AS160 in part explains insulin resistance at the molecular level in skeletal muscle in polycystic ovary syndrome. PMID: 17977950
    23. AS160, previously recognized as a key player in insulin signaling in skeletal muscle and adipose tissue, is also a major effector of protein kinase B/Akt signaling in the beta-cell. PMID: 18276765
    24. The transcript variant 2 of AS160 in contrast to full-length AS160 is a novel regulator of glucose transport that positively influences glucose-uptake rates. PMID: 18771725
    25. muscle TBC1D4 phosphorylation across the leg is increased during recovery following resistance exercise PMID: 18845784
    26. Specific phosphorylation of TBC1D4 in human skeletal muscle in response to physiological exercise-induced hyperinsulinemia. PMID: 19252894
    27. Prematurely truncated TBC1D4 protein tended to increase basal cell membrane GLUT4 levels (P = 0.053) and significantly reduced insulin-stimulated GLUT4 cell membrane translocation (P < 0.05). PMID: 19470471

    顯示更多

    收起更多

  • 相關疾病:
    Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)
  • 亞細胞定位:
    Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
  • 組織特異性:
    Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland,
  • 數據庫鏈接:

    HGNC: 19165

    OMIM: 612465

    KEGG: hsa:9882

    STRING: 9606.ENSP00000366863

    UniGene: Hs.210891



主站蜘蛛池模板: 精品国产三级a在线观看| 久久国产成人午夜av影院| 日韩一区二区三区精品| 亚洲性视频免费视频网站| 欧美精品黑人粗大免费| 中国china露脸自拍性hd| 蜜芽久久人人超碰爱香蕉| 国产精品爱啪在线播放| 伊人久久大香线蕉综合bd高清| 被窝的午夜无码福利专区| 亚洲午夜久久久精品影院| 久久精品一区二区三区四区| 精品av国产一二三四区| 中文人妻av大区中文不卡| 无码日韩做暖暖大全免费不卡| 久久精品午夜福利| 亚洲 自拍 另类小说综合图区| 在线v片免费观看视频| 最近最新中文字幕高清免费| 桃花色综合影院| 暖暖 免费 高清 日本 在线| 隔壁人妻被水电工征服| 综合五月激情二区视频| 国产精品无码成人午夜电影| 青青草国产精品一区二区| 女人爽到高潮视频免费直播| 无码丰满少妇2在线观看| 毛片24种姿势无遮无拦| 国产成人精品永久免费视频| 国产精品久久精品第一页| 熟女少妇人妻中文字幕| 欧美巨波霸乳影院| 欧洲女人性开放免费网站| 国产乱人伦真实精品视频| 久久亚洲私人国产精品| 成人亚洲精品久久99狠狠| 成年片色大黄全免费网站久久高潮| 又大又硬又爽免费视频| 亚洲乱亚洲乱妇24p| 欧美成人精品午夜免费影视| 国产sm重味一区二区三区|