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  4. TBC1D15 Antibody, HRP conjugated

TBC1D15 Antibody, HRP conjugated

  • 中文名稱：
    TBC1D15兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA823452LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TBC1D15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DKFZp686M1379 antibody; DKFZp761D0223 antibody; FLJ12085 antibody; FLJ33191 antibody; GAP for RAB7 antibody; GTPase-activating protein RAB7 antibody; RAB7 GAP antibody; Rab7-GAP antibody; TBC1 domain family member 15 antibody; TBC15_HUMAN antibody; Tbc1d15 antibody; Tre 2 budding uninhibited by benzimidazole cell division cycle 16 domain; domain family member 15 antibody; Tre2/Bub2/Cdc16 domain family member 15 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TBC1 domain family member 15 protein (283-404AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
  • 基因功能參考文獻：
    1. Report provides evidence for a new function of TBC1D15 in the control of GLUT4 vesicles translocation through regulating Rab7 activity. Glucose uptake was greatly reduced when TBC1D15 was knocked out. PMID: 30316925
    2. Demonstrate that TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating Rab7 activity at the interface between mitochondria and isolation membranes. PMID: 24569479
    3. TBC1D15 is required for the accumulation of RhoA. PMID: 24337944
    4. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
    5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
    6. This paper primarily describes mouse TBC1D15 but also reports the primary structure of human TBC1D15. PMID: 16055087

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  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 25694

    OMIM: 612662

    KEGG: hsa:64786

    STRING: 9606.ENSP00000448182

    UniGene: Hs.284630



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