在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TASP1 Antibody

  • 中文名稱:
    TASP1兔多克隆抗體
  • 貨號:
    CSB-PA023174GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TASP1
  • 別名:
    TASP1 antibody; C20orf13 antibody; Threonine aspartase 1 antibody; Taspase-1 antibody; EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TASP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protease responsible for KMT2A/MLL1 processing and activation. It also activates KMT2D/MLL2. Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A.
  • 基因功能參考文獻:
    1. Studies indicate that threonine Aspartase1 (Taspase1) is overexpressed in numerous liquid and solid malignancies and was characterized as a 'non-oncogene addiction' protease. PMID: 26657154
    2. simultaneous expression of the leukemogenic AF4-MLL and dnTASP1 causes the disappearance of the leukemogenic oncoprotein, because the uncleaved AF4-MLL protein (328 kDa) is subject to proteasomal degradation. PMID: 26137584
    3. Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2. PMID: 25996597
    4. inefficient heterodimerization appears to be the mechanism by which inactive Taspase1 variants fail to inhibit wild type Taspase1's activity in trans. PMID: 22570686
    5. Taspase1 appears to exploit the nuclear export activity of importin-alpha/nucleophosmin to gain transient access to the cytoplasm required to also cleave its cytoplasmic substrates. PMID: 21418451
    6. Cell-based analysis of structure-function activity of threonine aspartase 1. PMID: 21084304
    7. Taspase1 is overexpressed in primary human cancers, and deficiency of Taspase1 in cancer cells not only disrupts proliferation but also enhances apoptosis. PMID: 20516119
    8. purification and cloning of threonine aspartase 1 responsible for cleaving MLL; RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL and the loss of proper HOX gene expression PMID: 14636557
    9. Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. PMID: 16537915
    10. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha PMID: 18395097

    顯示更多

    收起更多

  • 蛋白家族:
    Ntn-hydrolase family
  • 數據庫鏈接:

    HGNC: 15859

    OMIM: 608270

    KEGG: hsa:55617

    STRING: 9606.ENSP00000338624

    UniGene: Hs.348297



主站蜘蛛池模板: 久久亚洲中文无码咪咪爱| 曰韩免费无码av一区二区| 男ji大巴进入女人的视频| 日日噜噜夜夜狠狠久久蜜桃| 国产成人精品三级在线影院| 男女啪啪抽搐高潮动态图| 777午夜精品免费观看| 波多野结衣av无码久久一区| 三男一女吃奶添下面视频| 1区2区3区高清视频| 无码人妻专区免费视频| 亚洲精品中国国产嫩草影院美女| 精品一区二区三区无码av久久| 成在线人永久免费视频播放| 妺妺窝人体色www在线小说| 国产在线一卡2卡三卡4卡免费| 无码av岛国片在线播放| 精品国产肉丝袜久久| 精品一区二区三区自拍图片区| 色偷偷av亚洲男人的天堂| а天堂中文地址在线| 丁香五月激情综合色婷婷| 成年女人片免费视频播放a| 人人添人人澡人人澡人人人人| 免费毛片全部不收费的| 久久熟妇人妻午夜寂寞影院| 亚洲精品无码久久久影院相关影片| 久久精品视频在线看| 午夜天堂精品久久久久| 国产白嫩漂亮美女在线观看| 欧美饥渴少妇xxxxx性| 精品乱人伦一区二区三区| 成人无码www免费视频| 重口sm一区二区三区视频| 国产av国片精品有毛| 在线观看免费人成视频| 日韩一区二区在线观看视频| 国产成人mv视频在线观看| 蜜柚av久久久久久久| 特级做a爰片毛片免费69| 免费刺激性视频大片区|