在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TAOK1 Antibody

TAOK1 Antibody

  • 中文名稱：
    TAOK1兔多克隆抗體
  • 貨號：
    CSB-PA040090
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2810468K05Rik antibody; AU020252 antibody; D130018F14Rik antibody; EC 2.7.11.1 antibody; FLJ14314 antibody; hKFC B antibody; hKFC-B antibody; KIAA1361 antibody; Kinase from chicken homolog B antibody; MAP3K16 antibody; MARK kinase antibody; MARKK antibody; MGC29021 antibody; Microtubule affinity regulating kinase kinase antibody; mKIAA1361 antibody; Prostate-derived sterile 20-like kinase 2 antibody; PSK2 antibody; Serine/threonine kinase TAO1 antibody; Serine/threonine protein kinase TAO1 antibody; Serine/threonine protein kinase TAO1 homolog antibody; Serine/threonine-protein kinase TAO1 antibody; STE20 like kinase antibody; STE20 like kinase PSK2 antibody; STE20-like kinase PSK2 antibody; TAO kinase 1 antibody; Taok1 antibody; TAOK1_HUMAN antibody; Thousand and one amino acid protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PSK2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
  • 基因功能參考文獻(xiàn)：
    1. we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt PMID: 28830982
    2. this study reveals a protective role for miR-706 by blocking the oxidative stress-induced activation of PKCalpha/TAOK1. Our results further identify a major implication for miR-706 in preventing hepatic fibrogenesis and suggest that miR-706 may be a suitable molecular target for anti-fibrosis therapy. PMID: 27876854
    3. This study reports a novel set of Dengue virus (DENV) NS1-interacting host cell proteins in the HepG2 cell line and proposes possible roles for human NEK2, TAO1, and COG1 in DENV infection. PMID: 27108190
    4. The TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. PMID: 24898139
    5. tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. PMID: 23585562
    6. Human TAO1 can phosphorylate and activate human MST2 PMID: 22075148
    7. Data do not support the notion that Tao1 is a component of the spindle checkpoint. PMID: 20162290
    8. the apparent role of the Tao1 kinase in spindle checkpoing signaling might in reality reflect an off-target effect produced by particular Tao1-directed siRNA oligonucleotides on Mad2 PMID: 19904549
    9. Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1 PMID: 16407310
    10. TAO kinases are regulators of p38-mediated responses to DNA damage and are intermediates in the activation of p38 by ATM. PMID: 17396146
    11. Dual functions of TAO1 in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in human cells. PMID: 17417629
    12. It is concluded that human TAO kinase 1 induces apoptosis in SH-SY5Y cells and the kinase domain is essential, but its catalytic activity seems to be dispensable in this case. PMID: 17900936
    13. Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability. PMID: 18216281

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29259

    OMIM: 610266

    KEGG: hsa:57551

    STRING: 9606.ENSP00000261716

    UniGene: Hs.597434



主站蜘蛛池模板： 亚洲综合天堂av网站在线观看| 中文字幕无码精品亚洲35| 无码成人aaaaa毛片| 日本丰满白嫩大屁股ass| 99久久无色码中文字幕| 好紧好爽好湿别拔出来视频男男| 一区二区无码免费视频网站| av无码天堂一区二区三区| 少妇被黑人4p到惨叫欧美人| 亚洲精品久久久久午夜aⅴ| 亚洲国产综合在线区尤物| 5858s亚洲色大成网站www| 国产亚洲精品久久久久久无几年桃 | 亚洲精品无码精品mv在线观看| 2021亚洲国产成a在线| 乱中年女人伦av三区| 天堂а√中文在线官网| 丁香五月激情综合色婷婷| 亚洲精品综合在线影院| 国产欧美日韩精品专区| 国内自拍五区| 亚洲精品国产精品国自产观看| 日本高清视频色wwwwww色| 国产在线码观看超清无码视频| 亚洲1卡二卡三新区2022| 无码人妻一区二区三区免费手机 | 国产农村乱对白刺激视频| 久久综合给合久久狠狠狠88| 人妻无码系列一区二区三区 | 久久久免费精品re6| 国产末成年av在线播放| 女人被躁到高潮免费视频软件| 国产乱人伦偷精精品视频| 天堂www中文在线资源| 寂寞骚妇被后入式爆草抓爆| 久久久774这里只有精品17| 国产乱人伦偷精精品视频| 少女韩国电视剧在线观看完整| 在线观看片免费人成视频播放| 99热成人精品国产免费| 综合五月激情二区视频|