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  4. TAF6L Antibody

TAF6L Antibody

  • 中文名稱：
    TAF6L兔多克隆抗體
  • 貨號：
    CSB-PA003697
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using PAF65α Polyclonal Antibody
    • Western Blot analysis of various cells using PAF65α Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TAF6L
  • 別名：
    TAF6L antibody; PAF65A antibody; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L antibody; TAF6L antibody; PCAF-associated factor 65-alpha antibody; PAF65-alpha antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PAF65α.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.
  • 基因功能參考文獻：
    1. immunohistochemical studies suggest that CBP, depending on the balance of nuclear proteins, is a component of AIRE nuclear bodies PMID: 15964547
    2. protein kinase C betaII augments NF-kappaB-mediated TNF-alpha-induced transcription of the target gene CCL11, promoting p65 association with the CCL11 promoter, in human airway smooth muscle cells by phosphorylating p300/CBP-associated factor PMID: 18714023
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TAF6 family
  • 數據庫鏈接：

    HGNC: 17305

    OMIM: 602946

    KEGG: hsa:10629

    STRING: 9606.ENSP00000294168

    UniGene: Hs.714400



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