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  4. TAF6 Antibody, HRP conjugated

TAF6 Antibody, HRP conjugated

  • 中文名稱：
    TAF6兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA023095LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAF6
  • 別名：
    TAF6 antibody; TAF2E antibody; TAFII70 antibody; Transcription initiation factor TFIID subunit 6 antibody; RNA polymerase II TBP-associated factor subunit E antibody; Transcription initiation factor TFIID 70 kDa subunit antibody; TAF(II)70 antibody; TAFII-70 antibody; TAFII70 antibody; Transcription initiation factor TFIID 80 kDa subunit antibody; TAF(II)80 antibody; TAFII-80 antibody; TAFII80 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.
  • 基因功能參考文獻：
    1. data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta PMID: 25025302
    2. The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways. PMID: 20096117
    3. a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a PMID: 15328371
    4. TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53 PMID: 18628956
  • 相關疾病：
    Alazami-Yuan syndrome (ALYUS)
  • 亞細胞定位：
    Nucleus.; [Isoform 4]: Nucleus.
  • 蛋白家族：
    TAF6 family
  • 數據庫鏈接：

    HGNC: 11540

    OMIM: 602955

    KEGG: hsa:6878

    STRING: 9606.ENSP00000399982

    UniGene: Hs.489309



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