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  4. TAF5L Antibody

TAF5L Antibody

  • 中文名稱：
    TAF5L兔多克隆抗體
  • 貨號：
    CSB-PA023093ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023093ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAF5L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAF5L
  • 別名：
    1110005N04Rik antibody; AI849020 antibody; OTTHUMP00000037470 antibody; OTTHUMP00000037471 antibody; PAF65 beta antibody; PAF65-beta antibody; PAF65B antibody; PCAF associated factor 65 beta antibody; PCAF-associated factor 65 beta antibody; TAF 5L antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor 65 kD antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor 65 kDa antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor antibody; TAF5 like RNA polymerase II p300/CBP associated factor associated factor 65 kDa subunit 5L antibody; TAF5 like RNA polymerase II p300/CBP associated factor associated factor 65kDa antibody; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L antibody; Taf5l antibody; Taf5l protein antibody; TAF5L_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L protein (1-325AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
  • 基因功能參考文獻：
    1. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
    2. The TAF5L gene on chromosome 1q42 is associated tie type 1 diabetes in Russian patients. PMID: 16206511
    3. p300 or PCAF maintains myoblast viability as effectively as added growth factors through mechanisms requiring the acetyltransferase activity of PCAF but not of p300. PMID: 16672693
    4. latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes PMID: 17476304
    5. PCAF is a histone acetyltransferase which regulates gene transcription. PCAF interacts physically and functionally with PTEN. PTEN acetylation by PCAF block the ability of PTEN to downregulate PI3-K signalling and to induce G1 cell cycle arrest. PMID: 16829519

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat TAF5 family
  • 數據庫鏈接：

    HGNC: 17304

    KEGG: hsa:27097

    STRING: 9606.ENSP00000258281

    UniGene: Hs.270621



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