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  4. TAF1B Antibody

TAF1B Antibody

  • 中文名稱：
    TAF1B兔多克隆抗體
  • 貨號：
    CSB-PA684476ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: TATA box-binding protein-associated factor RNA polymerase I subunit B antibody at 4μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 69, 61, 40 kDa
      Observed band size: 69 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA684476ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAF1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAF1B
  • 別名：
    TAF1B antibody; TATA box-binding protein-associated factor RNA polymerase I subunit B antibody; RNA polymerase I-specific TBP-associated factor 63 kDa antibody; TAFI63 antibody; TATA box-binding protein-associated factor 1B antibody; TBP-associated factor 1B antibody; Transcription initiation factor SL1/TIF-IB subunit B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit B protein (369-588AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
  • 基因功能參考文獻：
    1. AEP coactivator complex facilitates the initiation of RNAP2-dependent transcription via SL1 activity by loading TBP onto the TATA element. PMID: 26593443
    2. findings show that Rrn7, a subunit of the yeast Pol I core factor, and its human ortholog TAF1B are TFIIB-like factors PMID: 21921198
    3. TAF1B, a subunit of SL1, is structurally related to TFIIB/TFIIB-like proteins; SL1, essential for Pol I recruitment to rRNA gene promoter, also has an essential postpolymerase recruitment role, operating through TAF1B PMID: 21921199
    4. Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability. PMID: 12140758
    5. The four most frequently mutated genes in colorectal cancers with microsatellite instability were ACVR2 (92%), TAF1B (84%), ASTE1/HT001 (80%) and TGFBR2 (77%). PMID: 19503063

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  • 亞細胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    RRN7/TAF1B family
  • 數據庫鏈接：

    HGNC: 11533

    OMIM: 604904

    KEGG: hsa:9014

    STRING: 9606.ENSP00000263663

    UniGene: Hs.584833



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