在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TAF15 Antibody

  • 中文名稱:
    TAF15兔多克隆抗體
  • 貨號:
    CSB-PA954760
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA954760(TAF15 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA954760(TAF15 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, hepg2 cells, Raji cells, A431 cells, Primary antibody: CSB-PA954760(TAF15 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TAF15
  • 別名:
    68 kDa TATA-binding protein-associated factor antibody; Npl3 antibody; RBP56 antibody; RBP56_HUMAN antibody; RNA binding protein 56 antibody; RNA-binding protein 56 antibody; TAF antibody; TAF(II)68 antibody; TAF15 antibody; TAF15 RNA polymerase II TATA box binding protein (TBP) associated factor 68kDa antibody; TAF2N antibody; TAFII68 antibody; TATA-binding protein-associated factor 2N antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human TAF15
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
  • 基因功能參考文獻:
    1. weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation. PMID: 28945358
    2. In human stem cell-derived motor neurons, the RNA profile associated with concomitant loss of both TAF15 and FUS resembles that observed in the presence of the amyotrophic lateral sclerosis (ALS)-associated mutation FUS R521G, but contrasts with late-stage sporadic ALS patients. PMID: 27378374
    3. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. PMID: 28291257
    4. Aggregation of FET proteins FUS, EWSR1, and TAF15 mediate a pathological change in amyotrophic lateral sclerosis. (Review) PMID: 27311318
    5. Studies provide evidence that FUS/TLS, EWS and TAF15 proteins play a major role in neurodegenerative disorders. (review). PMID: 27415968
    6. O-GlcNAc glycosylation stoichiometry of TAF15 PMID: 27903134
    7. RNA binding by TAF-15 is dependent upon structural elements in the RNA rather than sequence. PMID: 26612539
    8. our data suggest that TAF15 and TLS/FUS operate within similar but not identical hnRNP M-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type. PMID: 24474660
    9. Data indicate that distinct differences in proteins becoming Poly(ADP-ribose) PARylated upon various genotoxic insults are observed, exemplified by the PARylation of RNA-processing factors THRAP3 and TAF15 under oxidative stress. PMID: 24055347
    10. TAF15 depletion inhibits growth & increases apoptosis. Its knockdown affects many genes involved in cell cycle & cell death. Among these, targets of microRNAs generated from the onco-miR-17 locus were overrepresented. PMID: 23128393
    11. Data show that FUS and TAF15 locate to cellular stress granules to a larger extend than EWS. FET-protein stress granule association most likely is a downstream response to cellular stress. PMID: 23049996
    12. The existence of a functionally discrete subset of U1 snRNP in association with TAF15 was suggested and provided further support for the involvement of U1 snRNP components in early steps of coordinated gene expression. PMID: 22019700
    13. TAF15 plays a role in RNA transport and/or local RNA translation PMID: 22771914
    14. Missense mutations of TAF-15, an RNA-binding protein, were found in patients with amyotrophic lateral sclerosis, and gene conferred neurodegeneration when expressend in Drosophila. PMID: 22065782
    15. REsults suggest the possibility that alterations of TAF15 and EWS might also be involved in the pathogenesis of FUS proteinopathies such as ALS and FTLD. PMID: 21856723
    16. Rare translocation t(12;17)(p13;q12), this translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases. PMID: 21504714
    17. These results suggest that additional studies are needed to determine whether mutations in the TAF15 gene represent a cause of familial amyotrophic lateral sclerosis. PMID: 21438137
    18. Elevated TAF15 mRNA levels did not translate to strongly elevated protein levels, consistent with its infrequent occurrence as translocation partner in tumors. PMID: 21344536
    19. Our findings define a role for a tumor-specific TAF15 antigen in malignant processes. PMID: 20048082
    20. The transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 or TAF15. PMID: 12359745
    21. hTAF(II)68-mediated transactivation is linked to the cytoplasmic Src signal transduction pathway. The hTAF(II)68 protein can associate with the SH3 domains of several cell signaling proteins, including v-Src. PMID: 15094065
    22. The oncogenic effect of the t(9;17) translocation may be due to the hTAF(II)68-TEC chimeric protein and that fusion of the hTAF(II)68 NTD to the TEC protein produces a gain of function chimeric product. PMID: 18330902
    23. FUS, EWS and TAF15 proto-oncoproteins were targeted to stress granules induced by heat shock and oxidative stress PMID: 18620564
    24. Data demonstrate that arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function. PMID: 19124016
    25. Data show that a fraction of human U1 snRNA specifically associates with the nuclear RNA-binding protein TBP-associated factor 15 (TAF15). PMID: 19282884
    26. These results suggest that caspase-mediated degradation may represent a novel regulatory mechanism that controls TAF15 and TAF15-CIZ/NMP4 activities. PMID: 19426707

    顯示更多

    收起更多

  • 相關疾病:
    A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm.
  • 蛋白家族:
    RRM TET family
  • 組織特異性:
    Ubiquitous. Observed in all fetal and adult tissues.
  • 數據庫鏈接:

    HGNC: 11547

    OMIM: 601574

    KEGG: hsa:8148

    STRING: 9606.ENSP00000466950

    UniGene: Hs.402752



主站蜘蛛池模板: 男女无遮挡xx00动态图120秒| 色欲色香天天天综合网www| 无码国产精品一区二区高潮| 亚洲欧美精品伊人久久| 免费国产a国产片高清网站| 欧美综合自拍亚洲综合图片区| 免费人成视频在线观看不卡| 亚洲精品乱码久久久久久日本麻豆| 色综合久久婷婷五月| 国产大片黄在线观看私人影院| 99国产精品人妻噜啊噜| 人与动人物xxxx毛片人与狍 | 99久久国语露脸精品国产色 | 97久久国产成人免费网站| 99久re热视频这里只有精品6| 久久www免费人成_看片中文| 熟妇人妻一区二区三区四区| 玩弄少妇高潮ⅹxxxyw| 国产在线精品99一卡2卡| 看国产一毛片在线看手机看| 人妻无码熟妇乱又伦精品视频| а天堂中文最新一区二区三区| 丰满少妇被猛烈进入高清播放| 国产女人精品视频国产灰线| 美女视频黄又黄又免费| 又黄又爽又色视频| 亚洲国产成人无码网站大全| 欧美国产成人精品一区二区三区| 亚洲粉嫩高潮的18p| 亚洲成a人片在线观看的电影| 国产无人区码一码二码三mba| 日本人妻丰满熟妇久久久久久| 无码专区 丝袜美腿 制服师生| 亚洲欧美日韩中文二区| 人妻精品人妻无码一区二区三区| 第九色区av天堂| 中文字幕亚洲乱码熟女一区二区| 久久久久久国产精品mv| 亚州中文字幕午夜福利电影| 性欧美vr高清极品| 国产精品一区二区av|