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  4. TAF12 Antibody

TAF12 Antibody

  • 中文名稱：
    TAF12兔多克隆抗體
  • 貨號：
    CSB-PA624102ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA624102ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA624102ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAF12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAF12
  • 別名：
    TAF12 antibody; TAF12 RNA polymerase II; TATA box binding protein (TBP)-associated factor; 20kDa antibody; TAF12_HUMAN antibody; TAF15 antibody; TAF2J antibody; TAFII 20/TAFII 15 antibody; TAFII-20/TAFII-15 antibody; TAFII20 antibody; TAFII20/TAFII15 antibody; Transcription initiation factor TFIID 20/15 kDa subunits antibody; Transcription initiation factor TFIID subunit 12 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription initiation factor TFIID subunit 12 protein (1-161AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.
  • 基因功能參考文獻：
    1. Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells PMID: 29316427
    2. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1 PMID: 27551064
    3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
    4. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
    5. TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. PMID: 17268553

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TAF12 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 11545

    OMIM: 600773

    KEGG: hsa:6883

    STRING: 9606.ENSP00000263974

    UniGene: Hs.530251



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