在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TACR3 Antibody

  • 中文名稱:
    TACR3兔多克隆抗體
  • 貨號(hào):
    CSB-PA023070ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA023070ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA023070ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) TACR3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    TACR3; NK3R; TAC3R; Neuromedin-K receptor; NKR; NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Neuromedin-K receptor protein (356-465AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
  • 基因功能參考文獻(xiàn):
    1. Three Single-nucleotide polymorphisms (on chromosomes 3 and 11) were associated with vasomotor menopause symptoms in the African American group. However, 14 Single-nucleotide polymorphisms, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, had similar effect sizes across studies/participants' ancestry. Genetic variation in TACR3 may contribute to the risk of vasomotor menopause symptoms. PMID: 28231077
    2. observations of interspecies variation in the neurokinin 3 receptor brain localization with more extensive distribution in guinea pig than in primate brain; in the human brain, specific binding to the neurokinin 3 receptor was highest in the amygdala and in the hypothalamus and very low in other regions examined PMID: 26993630
    3. High NK-3R expression is associated with Oral Squamous Cell Carcinoma. PMID: 29061792
    4. reduced to an almost undetectable level in polycystic ovary syndrome granulosa cells PMID: 27580802
    5. Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands. PMID: 27271543
    6. results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix PMID: 27919954
    7. None of the 4 single polymorphisms studied in TACR3 are linked directly to puberty onset time, but A63P in TAC3 is statistically associated with precocious puberty. PMID: 25153567
    8. Elevated CRP is likely a pathogenic factor contributing to preeclampsia by binding to phosphocholinated neurokinin B and preferentially activating NK3R. PMID: 25452470
    9. data indicate that GPR54 and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing PMID: 24434351
    10. Studies indicate the molecular mechanisms by which NK3R mutations cause GnRH deficiency. PMID: 24376026
    11. Expression of the gene encoding TACR3 is significantly up-regulated in leiomyomas, compared with matched myometrium. PMID: 23656837
    12. the rs2765 SNP predicted the degree of impairment of learning and memory in 209 elderly patients with cognitive impairments PMID: 23983264
    13. Data suggest that mutations in TACR3 and GNRHR are the most common causative mutations in normosmic idiopathic hypogonadotropic hypogonadism in families in Turkey. PMID: 22766261
    14. report of a Japanese female with hypogonadism(IHH) and compound heterozygous TACR3 mutations and her heterozygous parents; results suggest hypothalamic dysfunction as primary cause for IHH in patients with biallelic TACR3 mutations PMID: 20395662
    15. NK-3R plays a crucial role in hypothalamic gonadotropin releasing hormone release in humans. PMID: 20194706
    16. Results found no significant difference in the expression of tachykinins receptors between pre-eclamptic placenta and normal controls. PMID: 16709596
    17. Our results suggest that TACR3 is unlikely to be related to the development of schizophrenia in the Japanese population. PMID: 18287949
    18. small nucleotide polymorphisms in the 3' region of tachykinin receptor 3 gene (TACR3) provided significant evidence of association with alcohol dependence PMID: 18422838
    19. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. PMID: 19079066
    20. Homozygosity for the TACR3 His148Leu mutation leads to failure of sexual maturation in humans, whereas signaling by the mutant receptor in vitro in response to either NKB or senktide is severely impaired. PMID: 19755480

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)
  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11528

    OMIM: 162332

    KEGG: hsa:6870

    STRING: 9606.ENSP00000303325

    UniGene: Hs.942



主站蜘蛛池模板: 欧美白丰满老太aaa片| 尹人香蕉久久99天天拍欧美p7 | 欧美亚洲国产成人一区二区三区| 午夜dj高清免费观看视频| 久久久一本精品久久精品六六| 中文字幕一区二区三区乱码| 中文字幕色av一区二区三区| 中文字幕色av一区二区三区| 国产成人综合久久三区| 一个人看免费视频www| 最新精品国偷自产在线美女足| 中国亚洲女人69内射少妇| 免费国产a国产片高清网站| 少妇乳大丰满在线播放| 少妇又色又紧又爽又刺激视频| 巨爆乳无码视频在线观看| 久久久久99精品成人片牛牛影视| 国产午夜福利精品一区| 亚洲 日本 欧美 中文幕| 无码av中文字幕久久专区| www国产亚洲精品久久| 图片区小说区另类春色| 久久综合久久综合九色| 欧洲多毛裸体xxxxx| 伊人久久大香线蕉综合5g| 激情综合丁香五月| 日本三级吃奶头添泬无码苍井空 | 强开小婷嫩苞又嫩又紧视频| 成人精品一区日本无码网站| 亚洲在av极品无码| 精品国产三级a∨在线欧美| 欧美黑人又粗又大高潮喷水| 欧美成人a天堂片在线观看| 久久综合久中文字幕青草| 免费久久人人爽人人爽av| 成年午夜性影院免费观看| 毛片大全真人在线| 国产av一区二区三区最新精品 | 亚洲色大成网站www永久| 欧美老妇牲交videos| 国产饥渴孕妇在线播放|