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TACC2 Antibody

  • 中文名稱:
    TACC2兔多克隆抗體
  • 貨號:
    CSB-PA235316
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA235316(TACC2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TACC2
  • 別名:
    TACC2 antibody; Transforming acidic coiled-coil-containing protein 2 antibody; Anti-Zuai-1 antibody; AZU-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human TACC2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.
  • 基因功能參考文獻:
    1. This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma. PMID: 29843208
    2. These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases. PMID: 27333920
    3. Differential expression of the transcripts TACC2 connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
    4. Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer. PMID: 22456197
    5. Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. PMID: 22210879
    6. TACC2 may mediate an oncogenic effect on breast cancer cells. PMID: 20335520
    7. Defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. PMID: 12620397
    8. GCN5L2 is a TACC2-binding protein. PMID: 14767476
    9. Centrosomal TACC2 is required for mitotic spindle maintenance. PMID: 15304323
    10. Simian virus 40 large T antigen interacting with TACC2 is involved in stabilizing microtubules in mitosis. PMID: 19671663

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  • 亞細胞定位:
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    TACC family
  • 組織特異性:
    Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.
  • 數據庫鏈接:

    HGNC: 11523

    OMIM: 605302

    KEGG: hsa:10579

    STRING: 9606.ENSP00000334280

    UniGene: Hs.501252



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