在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SYNCRIP Antibody

  • 中文名稱:
    SYNCRIP兔多克隆抗體
  • 貨號:
    CSB-PA03334A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: SYNCRIP antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 70, 66, 63, 59, 47 kDa
      Observed band size: 70, 36 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA03334A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03334A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SYNCRIP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SYNCRIP
  • 別名:
    cytoplasmic RNA-interacting protein antibody; dJ3J17.2 antibody; Glycine and tyrosine rich RNA binding protein antibody; Glycine- and tyrosine-rich RNA-binding protein antibody; GRY RBP antibody; GRY-RBP antibody; GRYRBP antibody; Heterogeneous nuclear ribonucleoprotein Q antibody; hnRNP Q antibody; HNRPQ antibody; HNRPQ_HUMAN antibody; HNRPQ1 antibody; NS1 associated protein 1 antibody; NS1-associated protein 1 antibody; NSAP1 antibody; pp68 antibody; RP1 3J17.2 antibody; Synaptotagmin binding cytoplasmic RNA interacting protein antibody; Synaptotagmin-binding antibody; Syncrip antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Heterogeneous nuclear ribonucleoprotein Q protein (2-191AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,SYNCRIP Antibody (CSB-PA03334A0Rb),的標記方式是Non-conjugated。對于SYNCRIP Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA03334B0Rb SYNCRIP Antibody, HRP conjugated ELISA
    FITC CSB-PA03334C0Rb SYNCRIP Antibody, FITC conjugated
    Biotin CSB-PA03334D0Rb SYNCRIP Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
  • 基因功能參考文獻:
    1. A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets. PMID: 29483512
    2. our data indicate that hnRNP Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer PMID: 28079881
    3. SYNCRIP is required for survival of leukemia cells. SYNCRIP controls the myeloid leukemia stem cell program. PMID: 28436985
    4. The acidic domain is a unique structural feature of the splicing factor SYNCRIP. PMID: 27081926
    5. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
    6. The hnRNP Q is a novel substrate of SHP2 and the SHP2 activity may be also involved in RNA metabolisms via dephosphorylation of hnRNP Q. PMID: 23946508
    7. The inhibitory effect of hnRNP Q on YB-1 mRNA translation can be explained by its ability to pro-mote YB-1 binding to the regulatory element within the YB-1 mRNA 3' UTR. PMID: 23980891
    8. These data indicate that hnRNP Q can stimulate the protein production of HIV-1 Rev-dependent mRNAs without changing mRNA levels and mRNA export, respectively. PMID: 23679954
    9. Data demonstrate that expression levels of hnRNP A1, Q, K, R, and U influence HIV-1 production by persistently infected PMID: 19808671
    10. The overexpression of NSAP1 specifically enhanced HCV IRES-dependent translation, and knockdown of NSAP1 by use of a small interfering RNA specifically inhibited the translation of HCV mRNA. PMID: 15340051
    11. SYNCRIP is transported within the dendrite as a component of mRNA granules PMID: 15475564
    12. methylation of hnRNPQ is important for its nuclear localization PMID: 16765914
    13. Results suggest hnRNPQ interacts via its acidic domain (AcD) with Apobec1 and that this interaction is regulated by AcD phosphorylation. PMID: 17010310
    14. Data demonstrate that hnRNP Q is a splicing modulator of SMN2, further underscoring the potential of hnRNP Q as a therapeutic target for spinal muscular atrophy. PMID: 18794368
    15. Results demonstrate that galectin-3 stabilizes hnRNP Q via complex formation, and reduction in the hnRNP Q level leads to slow proliferation and less susceptibility to 5-FU. PMID: 19137262
    16. SYNCRIP participates in both RNA replication and translation in HCV life cycle. PMID: 19232660

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus.; [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.
  • 組織特異性:
    Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
  • 數據庫鏈接:

    HGNC: 16918

    KEGG: hsa:10492

    STRING: 9606.ENSP00000358635

    UniGene: Hs.571177



主站蜘蛛池模板: 欧美黑人又粗又大高潮喷水 | 麻豆精品传媒一二三区艾秋| 久久精品国产69国产精品亚洲| 免费精品99久久国产综合精品 | 欧美一区二区三区红桃小说| 国内老熟妇对白hdxxxx| 2020久久香蕉国产线看观看| 久久99热这里只有精品国产| 精品久久久久久无码人妻vr| 很黄很色60分钟在线观看| 狠狠色综合tv久久久久久| 欧美性大战久久久久久| 97无码免费人妻超级碰碰夜夜| 久久69精品久久久久久hb| 国内精品伊人久久久久妇| 一个人看的免费高清www视频| 少妇熟女高潮流白浆| 亚洲日韩久热中文字幕| 丁香狠狠色婷婷久久综合| 免费观看又污又黄的网站| 国产sm调教视频在线观看| 不卡无码av一区二区三区| 毛片免费观看天天干天天爽| 国产在线视频主播区| 亲嘴扒胸摸屁股激烈网站 | 日本高清中文字幕免费一区二区| 国产在线精品99一区不卡| 玩弄人妻少妇500系列| 伊人久久大香线蕉亚洲| 成人无码男男gv在线观看网站| 久久精品www人人做人人爽| 精品亚洲国产成人av| 国产精品成人国产乱| 亚洲狠狠色成人综合网| 老汉色老汉首页a亚洲| 中文字幕乱码熟妇五十中出色欲| 强开小婷嫩苞又嫩又紧视频| 高清欧美性猛交xxxx黑人猛交 | 97免费公开在线视频| 国产精品乱子伦xxxx裸| 玩两个丰满老熟女久久网|