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  4. SVBP Antibody, FITC conjugated

SVBP Antibody, FITC conjugated

  • 中文名稱：
    SVBP兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA836653LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SVBP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SVBP
  • 別名：
    SVBP antibody; CCDC23 antibody; Small vasohibin-binding protein antibody; Coiled coil domain-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Small vasohibin-binding protein (1-66AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation.
  • 基因功能參考文獻：
    1. identified a novel UPS regulatory system in which essential domain architecture (VASH-PS) of VASHs, comprising regions VASH191-180 and VASH280-169 , regulate the cytosolic punctate structure formation in the absence of SVBP. PMID: 27879017
    2. VASH2 contributes to the angiogenesis in hepatocellular carcinoma via an SVBP-mediated paracrine mechanism. PMID: 22614011
    3. SVBP(CCDC23)acts as a secretory chaperone for VASH1. PMID: 20736312
  • 亞細胞定位：
    Cytoplasm. Secreted. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    SVBP family
  • 數據庫鏈接：

    HGNC: 29204

    OMIM: 617853

    KEGG: hsa:374969

    STRING: 9606.ENSP00000361599

    UniGene: Hs.113919



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