在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUMO4 Antibody

  • 中文名稱:
    SUMO4兔多克隆抗體
  • 貨號:
    CSB-PA718803ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA718803ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SUMO4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SUMO4
  • 別名:
    dJ281H8.4 antibody; IDDM5 antibody; Small ubiquitin like modifier 4 protein antibody; Small ubiquitin-like protein 4 antibody; Small ubiquitin-related modifier 4 antibody; SMT3 suppressor of mif two 3 homolog 2 antibody; SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antibody; SMT3H4 antibody; SUMO 4 antibody; SUMO-4 antibody; SUMO4 antibody; SUMO4_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Small ubiquitin-related modifier 4 protein (1-95AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
  • 基因功能參考文獻(xiàn):
    1. meta-analysis demonstrated that the G allele of the SUMO4 M55V polymorphism could be a susceptible risk locus to type 2 diabetes mellitus, mainly in the Chinese population, while the association in other ethnic population needs to be further validated PMID: 28494838
    2. Both donor and recipient SUMO4 rs237025 polymorphisms contribute to the development of new-onset diabetes mellitus after liver transplantation. PMID: 28689037
    3. Results show that SUMO-4 is expressed in normal placental development. SUMO-4 expression was increased in pre-eclamptic placentas and in models of oxidative stress and hypoxic injury suggesting that SUMO-4 hyper-SUMOylation may be a potential post-translational mechanism in the stressed pre-eclamptic placenta. PMID: 28545138
    4. study suggests that SUMO4 c.163 G to A polymorphism is associated with the susceptibility to diabetic nephropathy in north Indian subjects with type 2 diabetes PMID: 27055882
    5. SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility. PMID: 25189908
    6. No association between SUMO4 gene polymorphisms and acoronary artery disease with and without type 2 diabetes mellitus. PMID: 23042402
    7. SUMO4 Met55Val variant was associated with increased insulin resistance in Chinese patients with newly diagnosed type 2 diabetes. PMID: 21671169
    8. study demonstrates significant associations of SUMO4 M55V polymorphism with type 1 diabetes mellitus in Asian and Caucasian population and with type 2 diabetes mellitus in Asian population PMID: 22936652
    9. The C438T polymorphism in the SUMO4 gene is associated with significantly increased risk of papulopustular skin lesions in HLA-B51-positive Behcet's disease patients. PMID: 21901353
    10. This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to type I diabetes in Asians and Europeans. PMID: 22884980
    11. the association between small ubiquitin-like modifier 4 (SUMO4) gene polymorphisms and type 2 diabetes mellitus PMID: 22425950
    12. Letter: report SUMO4 polymorphisms associated with protective effect in Tunisian rheumatoid arthritis patients. PMID: 21906435
    13. The SUMO4 gene single nucleotide polymorphism variant is not associated with susceptibility of the type 2 diabetes polymorphism. PMID: 20728233
    14. SUMO4 gene polymorphisms may be involved in the development of skin lesions, vascular Behcet's disease, as well as the severity of the disease. PMID: 20868570
    15. SUMO4 gene M55V variant is associated with the genetic susceptibility of type 1 diabetes mellitus (T1D) in Chinese children. PMID: 21158221
    16. This study suggests that in Taiwan the SUMO4 Met 55Val polymorphism is associated with susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse glycemic control. PMID: 19915388
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20728233
    18. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20448286
    19. Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20518843
    20. total of 2317 families were genotyped for 15 SNPs in the SUMO4 region. PMID: 19956095
    21. we report evidence for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval. PMID: 15247916
    22. SUMO4 sumoylation may play an important role in the regulation of intracellular stress PMID: 16236267
    23. The M55V polymorphism was significantly associated with type 1 diabetes in Asian populations . PMID: 16306380
    24. results indicate that the small ubiquitin-like protein 4(SUMO4) is a more common autoimmune disease gene and a supplementary risk factor to type 1 diabetes PMID: 16735488
    25. SUMO4 SNP did not significantly influence predisposition to and features of rheumatoid artritis, in contrast to previous genetic and functional evidence that suggested its involvement. PMID: 16755651
    26. Genetic and functional evidence is provided supporting SUMO4 as a type 1 diabetes mellitus susceptibility gene. PMID: 17130563
    27. No significant association was found between SUMO4 M55V and LADA. PMID: 17130565
    28. SUMO4 gene methionine-valine variant is associated with severity of diabetic nephropathy in patients with type 2 diabetes. PMID: 17229939
    29. Our results show that Asian-Indians with T1DM are different from other Asian populations. Asian-Indians show more similarity to Caucasians with respect to the association of SUMO4 M55V variant in T1DM. PMID: 17373940
    30. contribution of the SUMO4 Met55Val polymorphism to both type 1 and type 2 diabetes susceptibility in the Japanese population PMID: 17374705
    31. SUMO4 protein appears to be either in extremely low abundance in human kidney or HEK293 cells or it is not present at all.It remains possible that SUMO4 protein is more abundant in other cell types or can be induced by hormonal or environmental challenges PMID: 17459725
    32. we conclude that SUMO4 M55V is associated with type I diabetes melitus in association with high-risk HLA-DR3 and DR4, but not by itself. PMID: 17554341
    33. study of the prevalence of four polymorphisms,CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG in latent autoimmune diabetes in adults; no association with either of the polymorphisms has been found PMID: 17558709
    34. reported a positive association of the SUMO4 M55V variant with diabetic nephropathy in an Asian cohort of 430 patients with type 2 diabetes PMID: 17660269
    35. data indicate that the M55V polymorphism in the small ubiquitin-like protein 4(SUMO4) gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes PMID: 17926234
    36. we will update the genetic evidence supporting SUMO4 as a T1D susceptibility gene and discuss the possible explanations for the discrepant associations observed in Caucasians vs Asians.[review] PMID: 17990297
    37. no associations of the SUMO4 rs237025 A>G polymorphism with the susceptibility of psoriasis were detected. PMID: 18330586
    38. SUMO4 +438 C allele is associated with susceptibility to Behcet's Disease (BD) in HLA-B51 negative Chinese Han patients, while the AGAT haplotype is protectively associated with BD in HLA-B51 negative patients PMID: 18657476
    39. These data not only confirmed previously published data, but also provided additional evidence suggesting a role for SUMO4 sumoylation in the regulation of intracellular stress. PMID: 18708028
    40. This study examines whether small ubiquitin-like modifier 4 (SUMO4) polymorphisms were associated with Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population. PMID: 19122825
    41. SUMO4 may act as a negative feedback regulator to prevent excessive activation of NFkappaB. PMID: 19222990
    42. Association of the polymorphism of SUMO4 with risk of coronary heart disease in type 2 diabetes is suggested. PMID: 19410319
    43. Observational study of gene-disease association. (HuGE Navigator) PMID: 19915388
    44. Observational study of gene-disease association. (HuGE Navigator) PMID: 19410319
    45. Observational study of gene-disease association. (HuGE Navigator) PMID: 19122825
    46. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18466472
    47. Observational study of gene-disease association. (HuGE Navigator) PMID: 18466531
    48. Observational study of gene-disease association. (HuGE Navigator) PMID: 18330586
    49. Observational study of gene-disease association. (HuGE Navigator) PMID: 12901503
    50. Observational study of gene-disease association. (HuGE Navigator) PMID: 15730420

    顯示更多

    收起更多

  • 蛋白家族:
    Ubiquitin family, SUMO subfamily
  • 組織特異性:
    Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21181

    OMIM: 600320

    KEGG: hsa:387082

    STRING: 9606.ENSP00000318635

    UniGene: Hs.657168



主站蜘蛛池模板: 果冻传媒mv免费播放在线观看| 久久人人爽人人爽人人片av麻烦| 国产成人麻豆精品午夜福利在线| 国产精品尹人在线观看| 无码国产精品成人| 亚洲成a人v欧美综合天堂麻豆| 免费看男女做爰爽爽视频| 无码国模产在线观看免费| 在线亚洲中文精品第1页| 亚洲精品久久| 久久久亚洲精华液精华液精华液| 久久综合给合久久国产免费| 国产午夜理论不卡在线观看| 无码成人一区二区| 边啃奶头边躁狠狠躁| 日本少妇高潮喷水视频| 国产做爰xxxⅹ久久久小说| 日亚韩在线无码一区二区三区| 无码粉嫩虎白一线天在线观看| 国产精品久久久一区二区| 欧美极p品少妇的xxxxx| 亚洲中文无码人a∨在线| 国产无套中出学生姝| 久久精品国产亚洲一区二区| 国产超碰人人爽人人做av| 国产又色又爽又刺激在线观看| 丰满人妻熟妇乱又伦精品视| 久久精品无码一区二区app| 免费无码黄十八禁网站在线观看 | 亚洲欧洲国产综合aⅴ无码| 精品欧美成人高清在线观看| 亚洲日韩国产成网在线观看| 精品自拍亚洲一区在线| 国产精品天堂avav在线| 欧美 变态 另类 人妖| 日韩中文高清在线专区| 在线 国产 精品 蜜芽| 久久久久人妻精品一区三寸蜜桃| 亚洲gv猛男gv无码男同| 国产成人av一区二区三区无码| 亚洲精品国偷拍自产在线观看蜜桃|