在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SUCNR1 Antibody, Biotin conjugated

  • 中文名稱:
    SUCNR1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA022921LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SUCNR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SUCNR1; GPR91; Succinate receptor 1; G-protein coupled receptor 91; P2Y purinoceptor 1-like
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Succinate receptor 1 protein (303-334AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for succinate.
  • 基因功能參考文獻:
    1. activation of SUCNR1 in macrophages is important for both infiltration and inflammation of adipose tissue in obesity PMID: 28382382
    2. This study shows that metformin can attenuate activation of HSCs by activating the AMPK pathway and inhibiting the succinate-GPR91 pathway. Metformin has therapeutic potential for treating steatohepatitis and liver fibrosis. PMID: 29278707
    3. This study reports the expression of GPR91 on mouse and human mast cells and reveals a hyperactive behavior of mouse Sucnr1-/- mast cells in a mechanistic in vivo model of skin inflammation. PMID: 27527650
    4. Data show that succinate upregulates vascular endothelial growth factor (VEGF) expression by activation of signal transducer and activator of transcription 3 (STAT3) and extracellular regulated kinase (ERK)1/2 via its receptor G-protein coupled receptor 91 (GPR91). PMID: 28061458
    5. Succinate is abundant in synovial fluids from rheumatoid arthritis (RA) patients, and these fluids elicit IL-1beta release from macrophages in a GPR91-dependent manner. PMID: 27481132
    6. We give an exhaustive overview of the known and hypothetical signaling partners of SUCNR1 in different in vitro and in vivo systems and also discuss the link between SUCNR1 intracellular pathways and its pathophysiological roles. PMID: 26808164
    7. Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization and cardiac hypertrophy. [review] PMID: 26759054
    8. The findings indicate that succinate-GPR91 signaling may be involved in right ventricular hypertrophy via PI3K/Akt signaling in vivo and in vitro. PMID: 26824665
    9. results show that succinate plays an important role in HSC activation through GPR91 induction, and suggest that succinate and GPR91 may represent new therapeutic targets for modulating hepatic fibrosis PMID: 26051274
    10. These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy PMID: 25539979
    11. These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration. PMID: 23833031
    12. results show that GPR91 when expressed in HEK293s cells couples exclusively through the Galphai pathway and acts through Galphai not only to inhibit cAMP production but also to increase intracellular Ca(2+) PMID: 23770096
    13. A review of how neuron-derived factors, GPR91 and Semaphorin 3A, guide retinal vascularization and are major contributors to the pathogenesis of retinopathy of prematurity . PMID: 22497252
    14. Succinate stimulates cell proliferation through GPR91 and requires activation of the Erk MAPK pathway. PMID: 19204147
    15. This paper describes function in another species. PMID: 15141213
    16. GPR91 is a receptor for succinate and mediates succinate-induced hypertension. PMID: 15141213

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed specifically in kidney.
  • 數據庫鏈接:

    HGNC: 4542

    OMIM: 606381

    KEGG: hsa:56670

    STRING: 9606.ENSP00000355156

    UniGene: Hs.133181



主站蜘蛛池模板: 欧美亚洲高清国产| 婷婷俺也去俺也去官网| 欧美性生交xxxxx无码久久久 | 国产成人精品午夜福利不卡| 国产精品一区二区熟女不卡| 国产精品久久久久9999小说| 日韩一区二区三区北条麻妃| 狠狠色色综合站| 手机在线看永久av片免费| 亚洲综合无码一区二区三区| 国产真实伦在线观看视频| 国产成+人欧美+综合在线观看| 熟女少妇丰满一区二区| 成人欧美一区二区三区1314| 欧洲极品无码一区二区三区| av在线播放日韩亚洲欧我不卡| 法国伦理少妇愉情| 欧美日韩视频无码一区二区三| 欧美性生交xxxxx久久久| 国产成人精品日本亚洲| 亚洲成a∧人片在线播放调教| 欧美丰满熟妇xx猛交| 国产亚洲精品久久久久久打不开 | 高中国产开嫩苞实拍视频在线观看| 国产精品美女久久久网站| 日日拍夜夜嗷嗷叫国产| 国产午夜无码片免费| 国产日韩综合av在线观看一区| 少妇又紧又深又湿又爽视频| 亚洲精品无码久久久久| 亚洲国产成人av网站| 亚洲一区二区三区国产精品无码| 久久人人爽天天玩人人妻精品| 免费无码av片在线观看动漫 | 人妻精品制服丝袜久久久| 亚洲日本乱码中文在线电影| 男女裸体影院高潮| 忘忧草www中文在线资源| 日韩精品无码人成视频| 国产精品免费福利久久| 少妇性l交大片7724com|