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  4. SUCLG2 Antibody, HRP conjugated

SUCLG2 Antibody, HRP conjugated

  • 中文名稱：
    SUCLG2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA846636LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SUCLG2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SUCLG2
  • 別名：
    EC 6.2.1.4 antibody; G BETA antibody; GBETA antibody; GTP specific succinyl-CoA synthetase beta subunit antibody; GTP specific succinyl-CoA synthetase subunit beta antibody; GTP-specific succinyl-CoA synthetase subunit beta antibody; mitochondrial antibody; SCS betaG antibody; SCS-betaG antibody; SUCB2_HUMAN antibody; Succinate CoA ligase GDP forming beta subunit antibody; Succinate-Coenzyme A ligase; GDP-forming; beta subunit antibody; Succinyl CoA ligase GDP forming beta chain mitochondrial antibody; Succinyl CoA synthetase betaG chain antibody; Succinyl-CoA ligase [GDP-forming] subunit beta antibody; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial antibody; Succinyl-CoA synthetase beta-G chain antibody; SUCLG2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial protein (161-292AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  • 基因功能參考文獻：
    1. SUCLG2 has a sensitivity of 75% and a specificity of 80% to distinguish follicular carcinoma from follicular adenoma PMID: 28709933
    2. The absence of SUCLA2 and SUCLG2 in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism PMID: 25370487
    3. SUCLG2 has been identified as both a determinator of CSF amyloid beta-protein (1-42) levels and as attenuator of cognitive decline in Alzheimer's disease. PMID: 25027320
    4. Loss of SUCLG2 is associated with mitochondrial DNA depletion and results in mitochondrial depletion syndrome. PMID: 21295139
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily
  • 組織特異性：
    Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.
  • 數據庫鏈接：

    HGNC: 11450

    OMIM: 603922

    KEGG: hsa:8801

    STRING: 9606.ENSP00000419325

    UniGene: Hs.644919



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