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STX8 Antibody, Biotin conjugated

  • 中文名稱:
    STX8兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA892159LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STX8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STX8
  • 別名:
    CARB antibody; STX 8 antibody; Stx8 antibody; STX8_HUMAN antibody; Syntaxin-8 antibody; Syntaxin8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Syntaxin-8 protein (1-215AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
  • 基因功能參考文獻:
    1. Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes. PMID: 27094127
    2. Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4. PMID: 25523146
    3. Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability PMID: 25404741
    4. Syntaxin-8 regulates the endocytosis of TASK-1. PMID: 24743596
    5. These results suggest that STX8 mediates the recycling of CLDN16 and constitutes an important component of the CLDN16 trafficking machinery in the kidney. PMID: 24659781
    6. There are increases in CARB localized to intraneuronal neurofibrillary tangles and granulovacuolar degeneration in susceptible hippocampal and cortical neurons in Alzheimer's disease. PMID: 14991845
    7. syntaxin 8 contributes to the regulation of CFTR trafficking and chloride channel activity by the SNARE machinery PMID: 15039462
    8. Has two functionally distinct di-leucine-based motifs that act independently in its endocytic and exocytic processes. PMID: 17965969
    9. Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes. PMID: 18980942

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  • 亞細胞定位:
    Membrane; Single-pass type IV membrane protein.
  • 蛋白家族:
    Syntaxin family
  • 組織特異性:
    Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
  • 數據庫鏈接:

    HGNC: 11443

    OMIM: 604203

    KEGG: hsa:9482

    STRING: 9606.ENSP00000305255

    UniGene: Hs.431109



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